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Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death.
Carriba, P.; Jimenez, S.; Navarro, V.; Moreno-González, Inés; Barneda-Zahonero, Bruna; Moubarak, R.S.; Lopez-Soriano, J.; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Comella, Joan Xavier[et al.] (Cell Death & Disease, 2015-02-12)
The brains of patients with Alzheimer’s disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine that has a dual function in neuronal cells. On one hand, TNFα can activate neuronal apoptosis, and ...