Listar por autor "Navarro-Lobato, Irene"
Mostrando ítems 1-12 de 12
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A correlation of haloperidol-induced cognitive deficit with dysfunctional dopamine receptor activity in nonhuman primate.
(Dovepress, 2010-05-04)Haloperidol is an antipsychotic drug that acts through blockage of dopamine D2 receptors. Chronic administration of this antipsychotic drug in nonhuman primates induces a pronounced cognitive deficit. However, receptor ... -
A dynamic expression pattern of sGalpha(i2) protein during early period of postnatal rat brain development.
López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Blanco-Calvo, Eduardo
; Masmudi-Martín, Mariam; Navarro-Lobato, Irene; Khan, Zafaruddin[et al.] (Elsevier, 2008-10-07)
The function of sG alpha i2 protein in central nervous system is not well understood. Therefore to explore the possible role of this protein in postnatal brain development, we have analyzed the protein expression pattern ... -
Activation of caspase-3 pathway by expression of sGαi2 protein in BHK cells.
López-Aranda, Manuel Francisco; Navarro-Lobato, Irene; López-Téllez, Juan Félix; Blanco-Calvo, Eduardo; Masmudi-Martín, Mariam; Khan, Zafaruddin[et al.] (Elsevier, 2008)
Treatment with dopamine and other dopamine D2 receptor agonists has been shown to induce cell death through activation of caspase-3 pathway. However, initial step that leads to the activation of caspase-3 in D2 receptor-mediated ... -
Brain areas interconnected to ventral pathway circuitsare independently able to induce enhancement in objectrecognition memory and cause reversal in object recognitionmemory deficit.
Masmudi-Martin, Mariam; Navarro-Lobato, Irene; López-Aranda, Manuel Francisco; Quirós-Ortega, María Elena; Carretero-Rey, Marta; García-Garrido, María F.; López-Téllez, Juan Félix; Jiménez Recuerda, Inmaculada; Muñoz-de-León-López, Cristina; Khan, Zafaruddin[et al.] (Wiley, 2024)
Ventral pathway circuits are constituted by the interconnected brain areas that are distributed throughout the brain. These brain circuits are primarily involved in processing of object related information in brain. However, ... -
La esquizofrenia
Martín-Montañez, Elisa; Navarro-Lobato, Irene (UMA /SEDOC, 2012-04-24)
A día de hoy la ciencia sigue sin encontrar la respuesta a la causa que la provoca y solo puede diagnosticarse una vez el sujeto la padece. Una alteración mental repleta de síntomas asociados cuyo remedio de momento, sigue ... -
Implication of GluR2 subunit of AMPA receptor in RGS14(414)-mediated memory enhancement
Masmudi-Martín, Mariam; Navarro-Lobato, Irene; Bashir, Zafar I.; Khan, Zafaruddin (2016-07-12)
Ongoing quest for finding treatment against memory loss seen in aging and in many neurological and neurodegenerative diseases, so far has been unsuccessful and memory enhancers are seen as a potential remedy against this ... -
Prefrontal Inositol Triphosphate Is Molecular Correlate of Working Memory in Nonhuman Primates.
López-Téllez, Juan Félix; López-Aranda, Manuel Francisco; Navarro-Lobato, Irene; Masmudi-Martín, Mariam; Martín-Montañez, Elisa; Blanco-Calvo, Eduardo; Khan, Zafar U.[et al.] (Society for Neuroscience, 2010-02-24)
Working memory (WM) is a process of actively maintaining information in the mind for a relatively short period of time, and prefrontal cortex (PFC) has been thought to play a central role in its function. However, our ... -
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
Navarro-Lobato, Irene; Masmudi-Martín, Mariam; López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Delgado, Gloria; Granados-Durán, Pablo; Gaona-Romero, Celia; Carretero-Rey, Marta; Posadas, Sinforiano; Quirós-Ortega, María Elena; Khan, Zafaruddin[et al.] (Wolters Kluwer Medknow, 2023-11-08)
Memory deficit, which is often associated with aging and many psychiatric, neurological, and neurodegenerative diseases, has been a challenging issue for treatment. Up till now, all potential drug candidates have failed ... -
RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism
(Servicio de Publicaciones y Divulgación Científica, 2015)A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against ... -
Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory.
López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Navarro-Lobato, Irene; Masmudi-Martín, Mariam; Gutiérrez-Pérez, Antonia; Khan, Zafaruddin[et al.] (AAAS, 2009-07-03)
Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of ... -
ROLE OF RGS14 PROTEIN IN VISUALMEMORYAND THE REGULATION OF SYNAPTIC PLASTICITY IN PERIRHINAL CORTEX
Masmudi-Martin, Mariam; Posadas, Sinforiano Jose; Navarro-Lobato, Irene; Delgado, Gloria; López-Téllez, Juan Félix; Bashir, Zafar I.; Khan, Zafaruddin[et al.] (2013-10-31)
Though the concept of participation of perirhinal cortex and frontal cortex in the processing of object memory has long been appreciated, but recently our laboratory extended this to area V2 of visual cortex. We found that ... -
Role of RGS14(414) in object recognition memory and regulation of synaptic plasticity in perirhinal cortex
Al-Masmudi-Martín, Mariam; Posadas, S. J.; Navarro-Lobato, Irene; Delgado, Gloria; Bashir, Zafar I.; Khan, Zafaruddin[et al.] (2014-07-11)
Participation of perirhinal and frontal cortices in processing of object recognition memory has long been recognized, however, recently our laboratory extended this to area V2 of visual cortex. We observed that RGS14414-mediated ...