Listar por autor "Blanca, Miguel"
Mostrando ítems 1-10 de 10
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Anticonvulsant-induced Toxic Epidermal Necrolysis: Monitoring the Immunologic Response.
Leyva-Fernández, Laura
; Torres-Jaén, María Josefa; Posadas, Sinforiano Jose; Blanca, Miguel; Besso, Guillermo; O'Valle, Francisco; García del Moral, Raimundo; Santamaría, Luis F; Juárez, Carlos[et al.] (Elsevier BV, 2000)
Background Toxic epidermal necrolysis is a severe reaction with skin involvement induced by different drugs and other agents. The mechanisms implicated in the induction of the reaction are poorly understood. Objective To ... -
Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests.
Torres-Jaén, María Josefa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; Guzmán, Antonio-Eloy; Cornejo García, José Antonio; Juárez, Carlos; Blanca, Miguel[et al.] (Wiley, 2002)
Although subjects with a positive history of immediate allergy to penicillin and negative skin test are considered to tolerate penicillin, they may develop an immediate reaction despite negative skin and serum specific IgE ... -
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity.
Posadas, Sinforiano Jose; Padial, Antonia; Torres-Jaén, María Josefa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; Sánchez, Elena; Álvarez, Javier; Romano, Antonino; Juárez, Carlos; Blanca, Miguel; Sánchez, Elena[et al.] (Elsevier, 2002)
Background Drugs can induce different immunologic reactions; T-cell mediated responses produce the most severe reactions. Although in vitro studies show that T cells recognize drugs or their metabolites and induce an ... -
Dendrimeric Antigens. New Approaches Towards Detection of IgE‐Mediated Drug Allergy Reactions
Montañez-Vega, María Isabel; Mayorga, Cristobalina; Torres-Jaén, María Josefa; Ruiz-Sánchez, Antonio Jesús; Malkoch, M; Hult, A; Blanca, Miguel; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (RSC Publishing, 2013-05-31)
Drugs are low molecular weight substances which cannot cause an immune response on their own. However, they can act as haptens and form covalent adducts with proteins. The resulting hapten‐carrier (drug‐protein) conjugate ... -
Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions
Blanca, Miguel; Posadas, Sinforiano Jose; Torres-Jaén, María Josefa; Leyva-Fernández, Laura; Mayorga Mayorga, Cristobalina; González, Lourdes; Juárez, Carlos; Fernández, Javier; Santamaría, Luis F[et al.] (Wiley, 2000)
Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T lymphocytes may play a relevant role. T cells related to skin immune responses express the cutaneous ... -
In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions.
Luque, Inmaculada; Leyva-Fernández, Laura; Torres-Jaén, María Josefa; Rosal, Manuel; Mayorga Mayorga, Cristobalina; Segura, José Manuel; Blanca, Miguel; Juárez, Carlos[et al.] (Wiley, 2001)
Background: Beta-Lactam drugs may induce both cellular and humoral allergic reactions, and there is evidence that T cells play an important role in the pathogenesis of these reactions. The aim of this work was to assess ... -
Recognition of multiepitope dendrimeric antigens by human immunoglobulin E.
Montañez-Vega, María Isabel; Nájera-Albendín, Francisco; Mayorga, Cristobalina; Ruiz-Sánchez, Antonio Jesús; Vida-Pol, Yolanda; Collado-Martín, Daniel; Blanca, Miguel; Torres-Jaén, María Josefa; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (Elsevier, 2015-02-07)
In vitro drug allergy tests have limited sensitivity, partly due to a poor understanding of the immunological recognition of in vitro drug–protein conjugates. We have designed and synthesized multivalent mono- and bi-epitope ... -
Study of binding and neutralising antibodies to interferon-β in two groups of relapsing-remitting multiple sclerosis patients.
Fernández Fernández, Óscar; Mayorga Mayorga, Cristobalina; Luque, Gloria; Guerrero, Miguel; Guerrero, Rocío; Leyva-Fernández, Laura; León-Martín, Antonio; Blanca, Miguel[et al.] (Springer Nature, 2001)
Interferon (IFN)-β is generally considered an effective treatment for multiple sclerosis (MS); however, some patients do not respond to this therapy, possibly due to the production of neutralising antibodies (NAB) which ... -
Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction
Posadas, Sinforiano Jose; Leyva-Fernández, Laura; Torres-Jaén, María Josefa; Rodríguez-Bada, José Luis; Bravo, Inmaculada; Rosal, Manuel; Fernández, Javier; Juárez, Carlos; Blanca, Miguel[et al.] (Elsevier, 2000-10)
Background: The mechanisms involved in adverse drug reactions with an immunologic basis (ADRIB) can be antibody dependent, mainly IgE or T cell dependent (sensitized T cells). These mechanisms are regulated by a number of ... -
Unravelling adverse reactions to NSAIDs using systems biology.
(Cell Press, 2015-01-08)Unpredictable adverse drug reactions are non-dose-related reactions that appear only in susceptible individuals. Their biological basis remains a puzzle. Here we introduce the reader to systems biology using adverse drug ...