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Listar por autor "Jimenez-Guardeño, Jose Manuel"
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Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
Braga, Luca; Ali, Hashim; Secco, Ilaria; Chiavacci, Elena; Neves, Guilherme; Goldhill, Daniel; Penn, Rebecca; Jimenez-Guardeño, Jose Manuel; Ortega-Prieto, Ana Maria; Bussani, Rossana; Cannata, Antonio; Rizzari, Giorgia; Collesi, Chiara; Scheider, Edoardo; Arosio, Daniele; Ajay M, Shah; Barclay, Wendy S; Malim, Michael H.; Burrone, Juan; Giacca, Mauro[et al.] (Springer Nature, 2021)COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar ... -
Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies.
Martínez-Fernández, Diana Emilia; Fernández-Quezada, David; Casillas-Muñoz, Fidel Antonio Guadalupe; Carrillo-Ballesteros, Francisco Josué; Ortega-Prieto, Ana María; Jiménez-Guardeño, José Manuel; Regla-Nava, Jose Ángel[et al.] (2023-07-18)Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular-pustular skin lesions. However, the ... -
Identification of the mechanisms causing reversion to virulence in an attenuated SARS-CoV for the design of a genetically stable vaccine
Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Castaño-Rodriguez, Carlos; Fernandez-Delgado, Raul; Perlman, Stanley; Enjuanes, Luis[et al.] (Public Library of Science, 2015)A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the ... -
Immunoproteasome activation enables human TRIM5α restriction of HIV-1
Jiménez-Guardeño, José Manuel; Apolonia, Luis; Betancor, Gilberto; Malim, Michael H. (Springer Nature, 2019)Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties1. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally ... -
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
DeDiego, Marta L.; Nieto-Torres, Jose Luis; Regla-Nava, Jose Angel; Jimenez-Guardeño, Jose Manuel; Fernandez-Delgado, Raul; Fett, Craig; Castaño-Rodriguez, Carlos; Perlman, Stanley; Enjuanes, Luis[et al.] (ASM Journals, 2014)Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-ΔE) is attenuated ... -
Interferon-stimulated genes and their antiviral activity against SARS-CoV-2.
Ortega-Prieto, Ana María; Jiménez-Guardeño, José Manuel (American Society of Microbiology, 2024)The coronavirus disease 2019 (COVID-19) pandemic remains an international health problem caused by the recent emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of May 2024, SARS-CoV-2 has ... -
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
Skelton, Jessica Katy; Ortega-Prieto, Ana Maria; Kaye, Steve; Jimenez-Guardeño, Jose Manuel; Turner, Jane; Malim, Michael H.; Towers, Greg J.; Dorner, Marcus[et al.] (ASM Journals, 2019-05-15)Human immunodeficiency virus type 1 (HIV-1) infection is associated with aberrant immune activation; however, most model systems for HIV-1 have been used during established infection. Here, we utilize ultrasensitive HIV-1 ... -
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Seow, Jeffrey; Graham, Carl; Merrick, Blair; Acors, Sam; Pickering, Suzanne; Steel, Kathryn JA; Hemmings, Oliver; O'Byrne, Aoife; Kouphou, Neophytos; Galao, Rui Pedro; Betancor, Gilberto; Wilson, Harry D; Signell, Adrian W; Winstone, Helena; Kerridge, Claire; Huettner, Isabella; Jimenez-Guardeño, Jose Manuel; Lista, Maria Jose; Temperton, Nigel; Snell, Luke B; Bisnauthsing, Karen; Moore, Amelia; Green, Adrian; Martinez, Lauren; Stokes, Brielle; Honey, Johanna; Izquierdo-Barras, Alba; Arbane, Gill; Patel, Amita; Ik Tan, Mark Kia; O'Connell, Lorcan; O'Hara, Geraldine; MacMahon, Eithne; Douthwaite, Sam; Nebbia, Gaia; Batra, Rahul; Martinez-Nunez, Rocio; Shankar-Hari, Manu; Edgeworth, Jonathan D; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (2020)Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how ... -
MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation
Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Lynham, Steven; Antrobus, Robin; Khan, Hataf; Sobala, Andrew; Dicks, Matthew DJ; Malim, Michael H.[et al.] (Springer Nature, 2021)The antiviral cytokine interferon activates expression of interferon-stimulated genes to establish an antiviral state. Myxovirus resistance 2 (MX2, also known as MxB) is an interferon-stimulated gene that inhibits the ... -
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant
Graham, Carl; Seow, Jeffrey; Huettner, Isabella; Khan, Hataf; Kouphou, Neophytos; Acors, Sam; Winstone, Helena; Pickering, Suzanne; Galao, Rui Pedro; Dupont, Liane; Lista, Maria Jose; Jimenez-Guardeño, Jose Manuel; Laing, Adam G; Wu, Yin; Joseph, Magdalene; Muir, Luke; van Gils, Marit J; Ng, Weng M; Duyvesteyn, Helen ME; Zhao, Yuguang; Bowden, Thomas A; Shankar-Hari, Manu; Rosa, Annachiara; Cherepanov, Peter; McCoy, Laura E; Hayday, Adrian C; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (Elsevier, 2021)Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes ... -
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis
Nieto-Torres, Jose Luis; DeDiego, Marta L.; Verdiá-Báguena, Carmina; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Alcaraz, Antonio; Torres, Jaume; Aguilella, Vicente M; Enjuanes, Luis[et al.] (2014)Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function ... -
Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.
DeDiego, Marta L.; Nieto-Torres, José Luis; Jiménez-Guardeño, José Manuel; Regla-Nava, Jose Ángel; Álvarez, Enrique; Oliveros, Juan Carlos; Zhao, Jincun; Fett, Craig; Perlman, Stanley; Enjuanes, Luis[et al.] (PLOS, 2011)Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected ... -
The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis
Jimenez-Guardeño, Jose Manuel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Enjuanes, Luis[et al.] (2014)A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein ... -
TRIM5-mediated retrovirus restriction is modulated by type I interferon.
Ortega-Prieto, Ana María; Boehmer, Nina; Dinc, Hanife; Betancor, Gilberto; Petrosyan, Eduard; Malim, Michael H.; Jiménez-Guardeño, José Manuel[et al.] (2024)Since the identification in 2004 of the interferon-stimulated gene (ISG) tripartite motif-containing protein 5 α (TRIM5α) from rhesus macaques as a restriction factor preventing HIV-1 infection in these monkeys, the ...