Listar por autor "Fernández-Valenzuela, Juan José"
Mostrando ítems 1-18 de 18
-
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María
; Navarro, Victoria; Jiménez, Sebastián; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Mejias-Ortega, Marina; Fernández-Valenzuela, Juan José; Gómez-Arboledas, Ángela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Cognitive impairment acceleration after late-life depression in a model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Comparing astroglial reactivity in two transgenic mouse models of tauopathy
Fernández-Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; Sánchez-Mejías, Elisabeth; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2021-11-03)
Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
(UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Navarro, Victoria; Jiménez, Sebastián; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2018-07-20)
AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Romero-Molina, Carmen; Sánchez-Mejías, Elisabeth; Gómez-Arboledas, Ángela; Núñez-Díaz, Cristina; Navarro, Victoria; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-19)
Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; De Castro Carratalá, Vanessa; Moyano, Francisco; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2016-09-09)
AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ... -
Late-life depression accelerates cognitive decline in a tauopathy mouse model
Vegas-Gómez, Laura; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (IBRO/FENS, 2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Late-life depression is able to accelerate learning and memory impairment in a mouse model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-Gonzalez, Ines (CSHL, 2022)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno González, Inés; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2020-12-17)
Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-Gonzalez, Ines; Moyano, F; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Mitochondrial ultrastructural defects in reactive astrocytes of Alzheimer's mice hippocampus.
Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Fernández-Valenzuela, Juan José; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is a complex neurodegenerative condition that causes progressive memory loss and dementia. In AD brains astrocyte become reactive potentially contributing to cognitive decline. Astrocyte reactivity ... -
Protein homeostasis as a therapeutical target for Alzheimer’s disease: analysis in the hippocampus of transgenic mouse models
Sánchez-Varo, Raquel María; Criado-Álamo, Elena; Fernández-Valenzuela, Juan José; Mercado-Sáenz, Silvia; López-Villodres, Juan Antonio; Escamilla-Sanchez, Alejandro; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Ortega-Jiménez, Concepción; Alba-Tercedor, Carmen; Gutiérrez-Pérez, Antonia[et al.] (2022-09)
Alzheimer's disease (AD) constitutes the most prevalent form of dementia. There is no cure so there is an urgent need of novel therapeutic targets and treatments. The main histopathological hallmarks of AD brains are ... -
Systemic administration of epothylone-d recues memory and ameliorates Alzheimer’s disease-like pathology in APP/PS1 mice.
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; De Castro Carratalá, Vanessa; Moyano, Francisco José; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2017-04-17)
Aims Cognitive and memory decline in Alzheimer's disease (AD) patients is highly related to synaptic dysfunction and neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure, ... -
Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy
Fernández-Valenzuela, Juan José; López Oliva, Elba; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Romero, Carmen; Mejias-Ortega, Marina; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ... -
Ultrastructural evidence of mitochondrial pathology in hippocampal reactive astrocytes of β-amyloidosis Alzheimer’s transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Mejias-Ortega, Marina; Fernández-Valenzuela, Juan José; Gómez-Arboledas, Ángela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Cold Spring Harbor Laboratory, 2022)
Astrocytes, the most abundant non-neuronal cell type in the CNS, play essential roles in brain homeostasis and neuroprotection, including metabolic support, synaptic plasticity, cerebral blood flow and immunity. Many of ...