Listar por autor "Zafra, Rafael"
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A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep
Molina-Hernández, Verónica; Ruiz-Campillo, María Teresa; Martínez-Moreno, Francisco Javier; Buffoni, Leandro; Martinez Moreno, Álvaro; Zafra, Rafael; Bautista, María José; Escamilla-Sánchez, Alejandro
; Pérez-Caballero, Raúl; Pérez, José[et al.] (MDPI, 2021-09-30)
Fasciolosis is a parasitic disease of livestock causing important economic losses worldwide and it is also a zoonosis. Current therapy relies on the use of anthelmintic drugs, which is no longer sustainable due to the ... -
Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep
Escamilla-Sánchez, Alejandro; Pérez-Caballero, Raúl; Zafra, Rafael; Bautista, María José; Pacheco Luque, Isabel; Ruiz-Campillo, María Teresa; Martínez-Cruz, Setefilla; Martinez Moreno, Álvaro; Molina-Hernández, Verónica; Pérez, José[et al.] (Elsevier B.V., 2017-04)
Several immunomodulatory properties have been described in Fasciola hepatica infections. Apoptosis has been shown to be an effective mechanism to avoid the immune response in helminth infections. The aim of the present ... -
Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis
Pérez-Caballero, Raúl; Martínez-Moreno, Francisco Javier; Zafra, Rafael; Molina-Hernández, Verónica; Pacheco Luque, Isabel; Ruiz-Campillo, María Teresa; Escamilla-Sánchez, Alejandro; Pérez, José; Martinez Moreno, Álvaro; Buffoni, Leandro[et al.] (Springer Nature, 2018-12)
Se cree que las poblaciones celulares peritoneales (PCP) desempeñan un papel crucial durante la respuesta inmunitaria temprana en la infección por Fasciola hepatica mientras que los juveniles recién desenquistados (NEJ) ... -
Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with fasciola hepatica
Escamilla-Sánchez, Alejandro; Zafra, Rafael; Pérez, José; McNeilly, Tom; Pacheco Luque, Isabel; Buffoni, Leandro; Martínez-Moreno, Francisco Javier; Molina-Hernández, Verónica; Martinez Moreno, Álvaro[et al.] (Elsevier B.V., 2016-10)
Foxp3 regulatory T cells (Tregs) are now considered to play a key role in modulation of immune responses during parasitic helminth infections. Immunomodulation is a key factor in Fasciola hepatica infection; however, the ... -
Fasciola hepatica Induces Eosinophil Apoptosis in the Migratory and Biliary Stages of Infection in Sheep.
Escamilla-Sánchez, Alejandro; Bautista, María José; Zafra, Rafael; Pacheco Luque, Isabel; Ruiz-Campillo, María Teresa; Martínez-Cruz, Setefilla; Méndez, Aniceto; Martinez Moreno, Álvaro; Molina-Hernández, Verónica; Pérez, José[et al.] (Elsevier, 2016-01-30)
The aim of the present work was to evaluate the number of apoptotic eosinophils in the livers of sheep experimentally infected with Fasciola hepatica during the migratory and biliary stages of infection. Four groups (n ... -
Study of peritoneal macrophage immunophenotype in sheep experimentally infected with Fasciola hepatica
Ruiz-Campillo, María Teresa; Molina-Hernández, Verónica; Pérez, José; Pacheco Luque, Isabel; Pérez-Caballero, Raúl; Escamilla-Sánchez, Alejandro; Martínez-Moreno, Francisco Javier; Martinez Moreno, Álvaro; Zafra, Rafael[et al.] (Elsevier B.V., 2018-06-15)
During Fasciola hepatica infection, the parasite has the capability to modulate the host immune response towards a non-protector Th2 type instead of Th1. This type of immune response is closely related to the alternativ ... -
Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica
Pacheco Luque, Isabel; Abril, Nieves; Morales-Prieto, Noelia; Bautista, María José; Zafra, Rafael; Escamilla-Sánchez, Alejandro; Ruiz-Campillo, María Teresa; Martinez Moreno, Álvaro; Pérez, José[et al.] (Elsevier B.V., 2017-04)
The expression of IFNγ and IL4 was quantified using q-PCR in the liver and hepatic lymph nodes (HLN) of sheep during early stages of infection with Fasciola hepatica (1, 3, 9 and 18days post-infection, dpi). A group of ...