Listar por autor "Alvarez-Alvarez, Ismael"
Mostrando ítems 1-20 de 24
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A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry.
Bjornsson, Einar S.; Stephens, Camilla; Atallah, Edmond; Robles-Díaz, María Mercedes
; Alvarez-Alvarez, Ismael; Gerbes, Alexander L; Weber, Sabine; Stirnimann, Guido; Kullak-Ublick, Gerd A; Cortez-Pinto, Helena; Grove, Jane I.; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.[et al.] (Wiley, 2023)
Background & Aims: No multi-national prospective study of drug-induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short-term outcomes of the cases ... -
Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review
(Taylor & Francis, 2021-11-15)Introduction: Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. Areas ... -
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Villanueva-Paz, Marina; Aukštikalnė, Lauryna; Stephens, Camilla; Robles-Díaz, María Mercedes; Pinazo-Bandera, José M.; García-Cortés, Miren; Conde, Isabel; Soriano, German; Bessone, Fernando; Hernandez, Nelia; Nunes, Vinicius; Parana, Raymundo; Lucena-González, María Isabel; Andrade, Raúl J.; Alvarez-Alvarez, Ismael; Niu, Hao[et al.] (Springer Nature, 2023-12-05)
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess ... -
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; García-Cortés, Miren; Bonilla, Elvira; Niu, Hao; Soriano, German; Jiménez-Pérez, Miguel; Hallal, Hacibe; Blanco, Sonia; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2020-11-11)
Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries
García-Cortés, Miren; Ortega-Alonso, Aida; Matilla-Cabello, Gonzalo; Medina-Cáliz, Inmaculada; Castiella, Agustin; Conde, Isabel; Bonilla-Toyos, Elvira; Pinazo-Bandera, José M.; Hernandez, Nelia; Tagle, Martin; Nunes, Vinicius; Parana, Raymundo; Bessone, Fernando; Kaplowitz, Neil; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2023)
Background & aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), ... -
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Stephens, Camilla; Robles-Díaz, María Mercedes; Medina-Cáliz, Inmaculada; García-Cortés, Miren; Ortega-Alonso, Aida; Sanabria-Cabrera, Judith Adriana; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Slim, Mahmoud; Jiménez-Pérez, Miguel; González-Grande, Rocío; Fernández, M. Carmen; Casado, Marta; Soriano, German; Roman, Eva; Hallal, Hacibe; Romero-Gomez, Manuel; Castiella, Agustin; Conde, Isabel; Prieto, Martin; Moreno-Planas, José María; Giraldez, Alvaro; Moreno-Sanfiel, J Miguel; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2021-02-01)
Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Alvarez-Alvarez, Ismael; Sanabria-Cabrera, Judith Adriana[et al.] (MDPI, 2021-11-15)
Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Differential iNKT and T cells activation in non-alcoholic fatty liver disease and drug-induced liver injury.
Caballano-Infantes, Estefanía; García-García, Alberto; Lopez-Gomez, Carlos; Cueto-Sánchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Alvarez-Alvarez, Ismael; Arranz-Salas, Isabel María; Ruiz-Cabello, Francisco; Lucena-González, María Isabel; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (MDPI, 2021-01-28)
Background: Non-alcoholic fatty liver disease (NAFLD) and idiosyncratic drug-induced liver injury (DILI) could share molecular mechanisms involving the immune system. We aimed to identify activation immunological biomarkers ... -
Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach
González-Jiménez, Andrés; Suzuki, Ayako; Chen, Minjun; Ashby, Kristin; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Springer, 2021-03-05)
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of ... -
Drug-Induced Liver Injury in Latin America: 10-year experience of the Latin American DILI (LATINDILI) Network
Bessone, Fernando; Hernandez, Nelia; Medina-Caliz, Inmaculada; García-Cortés, Miren; Schinoni, María I.; Mendizabal, Manuel; Chiodi, Daniela; Nunes, Vinicius; Ridruejo, Ezequiel; Pazos, Ximena; Santos, Genario; Fassio, Eduardo; Parana, Raymundo; Reggiardo, Virginia; Tanno, Hugo; Sanchez, Adriana; Tanno, Federico; Montes, Pedro; Tagle, Martin; Arrese, Marco; Brahm, Javier; Girala, Marcos; Lizarzabal, M. Isabel; Carrera, Enrique; Zerega, Alina; Bianchi, Carla; Reyes, Laura; Arnedillo, Daina; Cordone, Antonella; Gualano, Gisela; Jaureguizahar, Fernanda; Rifrani, Gabriel; Robles‑Diaz, Mercedes; Ortega-Alonso, Aida; Pinazo-Bandera, Jose M.; Stephens, Camilla; Sanabria-Cabrera, Judith; Bonilla-Toyos, Elvira; Niu, Hao; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade, Raúl J.[et al.] (Elsevier, 2024-07)
Background and aims: Latin America is a region of great interest for studying the clinical presentation of idiosyncratic drug-induced liver injury (DILI). A comprehensive analysis of patients enrolled into the LATINDILI ... -
Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
Ashby, Kristin; Zhuang, Wei; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; Suzuki, Ayako; Chen, Minjun[et al.] (Elsevier, 2021)
Background & aims: Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 -12% developing a chronic disease. Herein, we ... -
Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
Cueto-Sánchez, Alejandro; Niu, Hao; Alvarez-Alvarez, Ismael; López-Longarela, Bárbara; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; García-Cortés, Miren; Pinazo-Bandera, José M.; Sanabria-Cabrera, Judith Adriana; Díaz-Monchón, Juan José; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Stephens, Camilla; Robles-Díaz, María Mercedes[et al.] (Wiley, 2023)
Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis ... -
Hepatitis C virus point-of-care microelimination approach in a vulnerable population in the South of Spain.
Pinazo-Bandera, Jose M.; Aranda, Jesús; García-García, Alberto M.; Alcántara, Ramiro; Ortega-Alonso, Aida; Del Campo-Herrera, Enrique; Clavijo-Frutos, Encarnación; García-Escaño, M. Dolores; Ruiz Ruiz, Juan J.; Morales-Herrera, Mónica; Valle-López, Vanesa; Martín-Alarcón, Rosa; Viciana, Isabel; Jiménez, Juan Bautista; Fernández-García, Félix; Toro-Ortiz, Juan Pedro; Sánchez-Yáñez, Elena; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús; Robles-Díaz, María Mercedes; García-Cortés, Miren[et al.] (Oxford Academic, 2024-01-22)
Background: Since the introduction of direct-acting antivirals, thousands of chronic hepatitis C patients have been successfully treated. However, vulnerable populations have a higher prevalence of hepatitis C virus (HCV) ... -
Herbal and dietary supplements-induced liver injury in Latin America: Experience from the LATINDILI Network
Bessone, Fernando; García-Cortés, Miren; Medina-Cáliz, Inmaculada; Hernandez, Nelia; Parana, Raymundo; Mendizabal, Manuel; Schinoni, María I.; Ridruejo, Ezequiel; Nunes, Vinicius; Peralta, Mirta; Santos, Genario; Anders, Margarita; Chiodi, Daniela; Tagle, Martin; Montes, Pedro; Carrera, Enrique; Arrese, Marco; Lizarzabal, M. Isabel; Alvarez-Alvarez, Ismael; Caballano-Infantes, Estefanía; Niu, Hao; Pinazo, Jose; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2022)
Background: Herbal and dietary supplements (HDS) consumption, a growing cause of hepatotoxicity, is a common practice among Latin-American populations. Objectives: To evaluate clinical, laboratory features and outcome ... -
N-acetylcysteine for the management of non-acetaminophen drug-induced liver injury in adults: a systematic review.
Sanabria-Cabrera, Judith Adriana; Tabbai-Amal, Sara; Niu, Hao; Alvarez-Alvarez, Ismael; Licata, Anna; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Frontiers, 2022)
Introduction: Idiosyncratic drug-induced liver injury (DILI) is a rare adverse reaction to drugs and other xenobiotics. DILI has different grades of severity and may lead to acute liver failure (ALF), for which there is ... -
Nitrofurantoin‑induced liver injury: long‑term follow‑up in two prospective DILI registries
Bessone, Fernando; Ferrari, Antonella; Hernandez, Nelia; Mendizabal, Manuel; Zerega, Alina; Tanno, Federico; Reggiardo, Maria Virginia; Vorobioff, Julio; Tanno, Hugo; Arrese, Marco; Nunes, Vinicius; Tagle, Martin; Medina-Cáliz, Inmaculada; Robles‑Diaz, Mercedes; Niu, Hao; Alvarez-Alvarez, Ismael; Stephens, Camilla; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer Nature, 2022-11-22)
Nitrofurantoin is a synthetic antibiotic that is recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American ... -
Potential benefit and lack of serious risk from corticosteroids in drug-induced liver injury: an international, multicentre, propensity score-matched analysis
Niu, Hao; Ma, Jiayi; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Bonilla-Toyos, Elvira; Ghabril, Marwan; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2022-12-22)
Background: The use of corticosteroids to treat patients with idiosyncratic drug-induced liver injury (DILI) relies on empirical clinical decisions. Aim: To investigate the relationship between corticosteroids and ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith Adriana; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Stankeviciute, Simona; Aithal, Guruprasad P.; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Sanabria-Cabrera, Judith Adriana[et al.] (Elsevier, 2021-02)
Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ... -
Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification
Niu, Hao; Solis-Muñoz, Pablo; García-Cortés, Miren; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Romero-Flores, Rocío; Bonilla-Toyos, Elvira; Ortega-Alonso, Aida; Pinazo-Bandera, José M.; Cabello-Porras, María Rosario; Bessone, Fernando; Hernandez, Nelia; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Medina-Cáliz, Inmaculada; Alvarez-Alvarez, Ismael[et al.] (Elsevier, 2023-12-08)
The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions
Pinazo-Bandera, José M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles-Díaz, María Mercedes; Hernandez, Nelia; Parana, Raymundo; Nunes, Vinicius; Girala, M.; Bessone, Fernando; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (Elsevier, 2024-05)
Los datos sobre la reexposición positiva en la lesión hepática inducida por fármacos (DILI) idiosincrásica son escasos. Apuntamos a analizar la presentación clínica, el resultado y los fármacos asociados con la reexposición ...