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Listar por autor "Lucena-González, María Isabel"
Mostrando ítems 21-39 de 39
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Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sanchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Ortega-Alonso, Aida; García-Cortés, Miren; González-Grande, Rocío; Jiménez-Pérez, Miguel; Ruiz-Cabello, Francisco; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Wiley, 2021-09-20)The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
Membrane vesicles of toxigenic Clostridioides difficile affect the metabolism of liver hepG2 cells
Caballano-Infantes, Estefanía; Ho-Plágaro, Ailec; López-Gómez, Carlos; Martín-Reyes, Flores; Rodríguez-Pacheco, Francisca; Taminiau, Bernard; Daube, Georges; Garrido Sánchez, Lourdes; Alcaín-Martínez, Guillermo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren; Lucena-González, María Isabel; García Fuentes, Eduardo; Rodriguez-Diaz, Cristina[et al.] (MDPI, 2023-03-27)Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease ... -
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Rodríguez-Agudo, Rubén; Goikoetxea-Usandizaga, Naroa; Serrano-Maciá, Marina; Fernández-Tussy, Pablo; Fernández-Ramos, David; Lachiondo-Ortega, Sofía; González-Recio, Irene; Gil-Pitarch, Clàudia; Mercado-Gómez, María; Bizkarguenaga, Maider; Lopitz-Otsoa, Fernando; Petrov, Petar; Bravo, Miren; Martijn Van Liempd, Sebastiaan; Falcón-Pérez, Juan Manuel; Zabala-Letona, Amaia; Carracedo, Arkaitz; Vicente Castell, Jose; Jover, Ramiro; Martínez-Cruz, Luis Alfonso; Cardoso Delgado, Teresa; Cubero, Francisco Javier; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Mabe, Jon; Simón, Jorge; Martínez-Chantar, María Luz[et al.] (IOAP-MPDI, 2022-04-30)Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without ... -
Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury
Rodriguez-Diaz, Cristina; Taminiau, Bernard; García-García, Alberto; Cueto-Sanchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Daube, Georges; Sanabria-Cabrera, Judith Adriana; Jiménez-Pérez, Miguel; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García Fuentes, Eduardo; García-Cortés, Miren[et al.] (Elsevier, 2022-08)The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders ... -
Nitrofurantoin‑induced liver injury: long‑term follow‑up in two prospective DILI registries
Bessone, Fernando; Ferrari, Antonella; Hernandez, Nelia; Mendizabal, Manuel; Zerega, Alina; Tanno, Federico; Reggiardo, Maria Virginia; Vorobioff, Julio; Tanno, Hugo; Arrese, Marco; Nunes, Vinicius; Tagle, Martin; Medina-Cáliz, Inmaculada; Robles‑Diaz, Mercedes; Niu, Hao; Alvarez-Alvarez, Ismael; Stephens, Camilla; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer Nature, 2022-11-22)Nitrofurantoin is a synthetic antibiotic that is recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American ... -
Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report
Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; De Boer, Ynto S.; Liberal, Rodrigo; Gerbes, Alexander L; Regev, Arie; Terziroli Beretta-Piccoli, Benedetta; Schramm, Christoph; Kleiner, David E.; De Martin, Eleonora; Kullak-Ublick, Gerd A; Stirnimann, Guido; Devarbhavi, Harshad; Vierling, John M.; Manns, Michael P.; Sebode, Marcial; Londoño, María Carlota; Avigan, Mark; Robles-Díaz, María Mercedes; García-Cortés, Miren; Atallah, Edmond; Heneghan, Michael; Chalasani, Naga; Trivedi, Palak J.; Hayashi, Paul H.; Taubert, Richard; Fontana, Robert J.; Weber, Sabine; Oo, Ye Htun; Zen, Yoh; Licata, Anna; Lucena-González, María Isabel; Mieli-Vergani, Giorgina; Vergani, Diego; Bjornsson, Einar S.[et al.] (Elsevier, 2023)Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint ... -
Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice
Villanueva-Paz, Marina; Morán, Laura; López-Alcántara, Nuria; Freixo, Cristiana; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Cubero, Francisco Javier[et al.] (MDPI, 2021-03-05)Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratoryabnormalitiestoacuteliverfa ... -
Papel del sistema inmune y la microbiota intestinal en el daño hepático inducido por fármacos. Búsqueda de nuevos biomarcadores.
Cueto Sánchez, Alejandro José (UMA Editorial, 2023)El daño hepático inducido por fármacos (DILI) es una condición infrecuente, pero puede tener consecuencias graves para los pacientes, ya que puede resultar en fallo hepático fulminante. El mecanismo subyacente de DILI no ... -
Potential benefit and lack of serious risk from corticosteroids in drug-induced liver injury: an international, multicentre, propensity score-matched analysis
Niu, Hao; Ma, Jiayi; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Bonilla-Toyos, Elvira; Ghabril, Marwan; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2022-12-22)Background: The use of corticosteroids to treat patients with idiosyncratic drug-induced liver injury (DILI) relies on empirical clinical decisions. Aim: To investigate the relationship between corticosteroids and ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Elsevier, 2021-12)Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith Adriana; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Stankeviciute, Simona; Aithal, Guruprasad P.; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Sanabria-Cabrera, Judith Adriana[et al.] (Elsevier, 2021-02)Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ... -
Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification
Niu, Hao; Solis-Muñoz, Pablo; García-Cortés, Miren; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Romero-Flores, Rocío; Bonilla-Toyos, Elvira; Ortega-Alonso, Aida; Pinazo-Bandera, José M.; Cabello-Porras, María Rosario; Bessone, Fernando; Hernandez, Nelia; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Medina-Cáliz, Inmaculada; Alvarez-Alvarez, Ismael[et al.] (Elsevier, 2023-12-08)The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and ... -
Profile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reports
Santos, Genario; Gasca, Jessica; Parana, Raymundo; Nunes, Vinicius; Schinnoni, Maria; Medina-Cáliz, Inmaculada; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (WILEY, 2020-06)Hepatotoxicity related to HDS is a growing global health issue. We have undertaken a systematic review of published case reports and case series from LA from 1976 to 2020 to describe the clinical features of HDS related ... -
Proteína c activada y polimorfismo genético en la sepsis grave
García de la Torre, Ángela (Universidad de Málaga, Servicio de Publicaciones, 2011)Introducción: La proteína C activada (APC) tiene propiedades antianticoagulantes, profibrinoliticas, antiinflamatorias, antiapoptósicas y de estabilización de la membrana endotelial en la sepsis. Objetivos: Determinar ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions
Pinazo-Bandera, José M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles-Díaz, María Mercedes; Hernández, N.; Parana, Raymundo; Nunes, Vinicius; Girala, M.; Bessone, Fernando; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (Elsevier, 2024-05)Los datos sobre la reexposición positiva en la lesión hepática inducida por fármacos (DILI) idiosincrásica son escasos. Apuntamos a analizar la presentación clínica, el resultado y los fármacos asociados con la reexposición ... -
Recreational Drugs and the Risk of Hepatocellular Carcinoma
Pinazo-Bandera, José M.; García-Cortés, Miren; Segovia-Zafra, Antonio; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús (IOAP-MPDI, 2022-11-02)Hepatocellular carcinoma represents an important contributor to the global cancer-related burden, and liver cirrhosis is the main risk factor for its development. Conventional or illegal drug consumption is a potential but ... -
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
Lucena-González, María Isabel; Villanueva-Paz, Marina; Alvarez-Alvarez, Ismael; Aithal, Guruprasad P.; Bjornsson, Einar S.; Cakan-Akdogan, G.; Cubero, Francisco Javier; Esteves, Freddy; Falcón-Pérez, Juan Manuel; Fromenty, B.; Garcia-Ruiz, C.; Grove, J.I.; Konu, O.; Kranendonk, M.; Kullak-Ublick, Gerd A; Miranda, J.P.; Remesal-Doblado, A.; Sancho-Bru, P.; Nelson, L.; Andrade-Bellido, Raúl Jesús; Fernandez-Checa, J.C.[et al.] (Elsevier, 2023-12-28)In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, ... -
Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury
Ulzurrun, Eugenia; Stephens, Camilla; Crespo, Esperanza; Ruiz-Cabello, Francisco; Ruiz-Nuñez, Julia; Saenz-López, Pablo; Moreno-Herrera, Inmaculada; Robles-Díaz, María Mercedes; Hallal, Hacibe; Moreno-Planas, José María; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (WILEY, 2013-04)Background & aims: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug-induced liver injury ... -
Serious liver injury induced by Nimesulide: an international collaboration study reporting 57 cases
Bessone, Fernando; Hernandez, Nelia; Mendizabal, Manuel; Ridruejo, Ezequiel; Gualano, Gisela; Fassio, Eduardo; Peralta, Mirta; Fainboim, Hugo; Anders, Margarita; Tanno, Hugo; Tanno, Federico; Parana, Raymundo; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Alvarez-Alvarez, Ismael; Niu, Hao; Stephens, Camilla; Colombato, Luis; Arrese, Marco; Reggiardo, Maria Virginia; Ono, Suzane Kioko; Carrilho, Flair; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer, 2021-03-24)Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries. We aim to analyze the clinical phenotype, outcome, and histological features of nimesulide-induced liver injury (nimesulide-DILI). We ...