Listar por autor "Moreno-González, Inés"
Mostrando ítems 21-40 de 42
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Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María
; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Del Rio, Juan Carlos; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Sage, 2009-11-12)
Here we demonstrated that extracellular, not intracellular, Aβ and the associated cytotoxic glial neuroinflammatory response are major contributors of early neuronal loss in a PS1xAPP model. A significant loss of principal ... -
Glutaminase activity is confined to the mantle of the islets of Langerhans.
Montero, Fernando; Baglietto-Vargas, David; Moreno-González, Inés; López-Téllez, Juan Félix; Cuesta Muñoz, Antonio L.; Gutiérrez-Pérez, Antonia; Aledo-Ramos, Juan Carlos[et al.] (Elsevier, 2007)
Glutamatergic signalling plays an important role in the coordination of hormone secretion from the endocrine pancreas. Thus, glutamate production must be a process exquisitely regulated to ensure a proper transmitter ... -
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada, Laura Isabel; Jiménez, Sebastián; De Castro, Vanessa; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; Navarro, Victoria; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2013)
Background: Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ... -
Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.
Caballero, Cristina; Jiménez, Sebastián; Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Gavilán, M. Paz; Ramos, Blanca; Del Río, Juan Carlos; Vizuete, María Luisa; Gutiérrez-Pérez, Antonia; Ruano, Diego; Vitorica Ferrández, Javier[et al.] (Wiley, 2007-01-22)
La detección de las primeras modificaciones fenotípicas de los modelos de la enfermedad de Alzheimer (EA) es fundamental para comprender la progresión e identificar dianas farmacológicas de esta patología. Sin embargo, se ... -
Late-life depression accelerates cognitive decline in a tauopathy mouse model
Vegas-Gómez, Laura; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (IBRO/FENS, 2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Late-life depression accelerates cognitive impairment and tau-associated pathology in an Alzheimer´s disease model.
Vegas-Gómez, Laura; Gutiérrez-Sastre, Cristina; Arredondo-Alcalá, María Ángeles; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Late-life depression is able to accelerate learning and memory impairment in a mouse model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (CSHL, 2022)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Litio como terapia neuroprotectora en el modelo APPSL/PS1M146L de la enfermedad de Alzheimer.
Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro Carratalá, Vanessa; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2013)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2020-12-17)
Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Moyano, F; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
Gavilán, M. Paz; Revilla, Elisa; Pintado, Cristina; Castaño, Angélica; Vizuete, María Luisa; Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; Ruano, Diego[et al.] (Wiley, 2007-06-29)
Increased neuroinflammatory reaction is frequently observed during normal brain aging. However, a direct link between neuroinflammation and neurodegeneration during aging has not yet been clearly shown. Here, we have ... -
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
(Springer Nature, 2017)Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Peripheral delivery of neural precursor cells ameliorates parkinson’s disease-associated pathology
(MDPI, 2019)Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Mejías-Ortega, Marina; Gómez-Arboledas, Ángela; Jimenez, Sebastian; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; Baglietto-Vargas, David; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Frontiers, 2021-11-04)
Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ... -
Segregation of two glutaminase isoforms in islets of Langerhans.
Baglietto-Vargas, David; López-Téllez, Juan Félix; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; Aledo-Ramos, Juan Carlos (Portland Press, 2004-01-31)
Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine ... -
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo
(Springer Nature, 2017)Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ...