Listar por autor "Ruiz-Gómez, Miguel José"
Mostrando ítems 21-40 de 53
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Identificación de nuevas proteínas relacionadas con la resistencia a radiación ionizante y el envejecimiento celular en S. cerevisiae
(UMA Editorial, 2023-03-03)Introducción: La aparición de resistencia a radiación en células tumorales expuestas constituye un problema en el abordaje terapéutico de algunos tumores. La radiorresistencia es una preocupación grave, pues provoca un ... -
Impact of compulsory participation of medical students in a multiuser online game to learn radiological anatomy and radiological signs within the virtual world Second Life
Rudolphi Solero, Teodoro; Lorenzo Álvarez, Rocío; Ruiz-Gómez, Miguel José
; Sendra-Portero, Francisco (Wiley, 2021-08-27)
Competitive game- based learning within Second Life enables effective teaching of basic radiological anatomy and radiological signs to medical students, with good ac-ceptance and results when students participate voluntarily, ... -
Improving oral presentation skills for radiology residents through clinical session meetings in the virtual world Second Life
Pino-Postigo, Alberto; Domínguez-Pinos, Dolores; Lorenzo Álvarez, Rocío; Pavía-Molina, José; Ruiz-Gómez, Miguel José; Sendra-Portero, Francisco[et al.] (MDPI, 2023-03-08)
Background: The objective of this study was to conduct a clinical session meeting in the virtual world of Second Life to improve the oral presentation skills of radiology residents and to assess the perception of the ... -
In silico analysis to identify the core genes implicated in colorectal cancer radiation resistance.
Burgos-Molina, Antonio Manuel; Rodríguez-García, Marta; González-Vidal, Alejandro; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2024)
Twenty-one proteins have been identified that act with different molecular mechanisms and that, to a greater or lesser extent, induce radiation resistance in colorectal cancer cells that overexpress them. The in-silico ... -
Increased resistance to drugs and longer life cycle by the administration of exogenous agents to normal human cells
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
Exogenous HSP70 provides protection against oxidative stress and that it could be a good therapeutic strategy to treat age-related macular degeneration. On the other hand, externally inoculating a heat shock protein to ... -
Intestinal microbiota and colorectal cancer
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Morales-Moreno, Francisco; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
Colorectal cancer may be influenced by changes in the intestinal microbiota that affect the mucosa and cause an immune response capable of producing inflammatory effects. Although there are still few studies in this regard, ... -
Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae
Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance. This mechanism could explain the tumor resistance observed in ... -
Metabolism is altered in the process of drug resistance acquisition
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need energy to survive, therefore, they increase the different pathways available to obtain it. This suggests that the cell, due to the cytotoxicity of bleomycin, increases the routes to obtain energy. For this reason, ... -
Methods to study the intestinal microbiota to address the disease in a more precise and personalized way
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
FISH, clone collection, DGGE, PCR and metagenomics techniques contribute to the study of the human microbiota in a precise and effective way, constituting very useful diagnostic tools in precision medicine to address patient ... -
Microbiota and body axes as a new therapeutic approach in precision medicine
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
There is a marked relationship between the composition and diversity of the microbiota and various diseases distant from the intestine. This relationship occurs through different body axes between the intestine and the ... -
Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity.
González Vidal, Alejandro; Mercado-Sáenz, Silvia; Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Alcaraz, Miguel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (MDPI, 2023-08-30)
The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence ... -
New markers of bleomycin resistance
Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment. The aim of this work is to carry out a ... -
One hundred of cells generations connect the resistance to drugs and the replicative aging mechanisms
There are researchs that reveal a relationship between acquired resistance to antineoplastic drugs and aging. Therefore, the identification of genes involved in senescence could have a potential therapeutic utility for ... -
Patentabilidad ¿Necesidad curricular o beneficio económico?
Ruiz-Gómez, Miguel José (2022-05-06)
El derecho a la propiedad industrial se recoge en las Leyes 2/201, 14/2011 y 24/2015. Esta normativa se incluye en la Ley 16/2007 Andaluza y se recoge en el Reglamento 3/2020 de la Universidad de Málaga. El derecho pertenece ... -
Presence of radon pollution in buildings and risk of cancer
Burgos-Molina, Antonio Manuel; Ruiz González, Óscar M.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
Radon gas present in the ground penetrates into homes through different routes, accumulating especially in rooms close to the ground. The dose received from radioactivity due to inhalation of radon inside houses poses a ... -
Proteins involved in carbon metabolism induce bleomycin resistance
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz González, Óscar M.; Ruiz-Gómez, Miguel José[et al.] (Aseica, 2022)
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes overexpression of TPIS protein. It could be involved in the resistance process. For this reason, it could be good candidates ... -
Proteomic analysis in wild type and cisplatin resistant yeast strain of saccharomyces cerevisiae
Research carried out in oncology has allowed the identification and characterization of molecular markers of resistance to antineoplastic drugs. It supposes a great advance and allows the administration of customized ... -
Pulsed magnetic feld increases the efect of ultraviolet C radiation and thermal shock in aged yeasts
Mercado-Sáenz, Silvia; González-Vidal, Alejandro; Burgos-Molina, Antonio Manuel; López-Díaz, Beatriz; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (Springer, 2023)
The study of the efects of the magnetic feld (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the ... -
Regulation of AURKA, BIRC5 and PLK1 protein expression in colorectal cancer
Burgos-Molina, Antonio Manuel; Rodríguez-García, M.; González-Vidal, A.; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (ASEICA, 2024-11)
AURKA, BIRC5 and PLK1 proteins show multiple regulatory transcription factors, highlighting E2F7, DRAP1 and ZNF511. The regulation of these protein is important to modulate the progression of cell cycle, cell proliferation, ... -
Relación entre envejecimiento celular y resistencia adquirida a Cisplatino y Bleomicina en Saccharomyces cerevisiae
Burgos-Molina, Antonio Manuel (UMA Editorial, 2017)
El cáncer es la principal causa de muerte en muchos países del mundo En las próximas décadas se convertirá en la principal causa de morbilidad y mortalidad en todas las regiones, indistintamente del nivel de recursos ...