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Listar por autor "Santín-Núñez, Luis Javier"
Mostrando ítems 21-40 de 100
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Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas-Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier[et al.] (2019-07-03)Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-11-18)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; Allén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2019-09-12)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
García-Cantero, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2021-01-22)The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
Effects of galanin n-terminal fragment (1-15) in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-21)Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. The intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) and an ... -
Effects of palmitoylethanolamide in cocaine-induced behaviours
Santín-Núñez, Luis Javier; Zambrana-Infantes, Emma; Galeano, Pablo; Rosell-del-Valle, Cristina; Ladrón de Guevara-Miranda, David; Castilla-Ortega, María Estela; Rodriguez-de-Fonseca, Fernando; Blanco-Calvo, Eduardo[et al.] (2016-07-13)Aims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels ... -
Effects of sequential exposure to physical exercise and cognitive training on hippocampal neurogenesis in mice
Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Mullor-Vigo, Rosa; Pérez-Berlanga, José Manuel; Zambrana-Infantes, Emma; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David[et al.] (2022-07-13)AIMS: Physical exercise and cognitive training hippocampal dependent tasks are known to enhance adult hippocampal neurogenesis (AHN). Here we aimed to evaluate the effect of either a moderate-intensity exercise protocol, ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas-Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier[et al.] (2019-10-01)Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-06-28)Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice
Mañas-Padilla, María del Carmen; Tezanos, Patricia; Cintado, Elisa; Vicente, Lucía; Sánchez-Salido, Lourdes; Gil-Rodríguez, Sara; Trejo-Pérez, José Luis; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-11-16)Cocaine is a widely used psychostimulant drug whose repeated exposure induces persistent cognitive/emotional dysregulation, which could be a predictor of relapse in users. However, there is scarce evidence on effective ... -
GAL(1-15) induces a depression and anxiogenic effect trough GALR1/GALR2 heteroreceptor: siRNA GALR1/GALR2 knockdown rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
Galanin (1-15) and escitalopram combination in rats reduces alcohol consumption in the ethanol self-administration test and improves escitalopram effects in the forced swimming test.
Cantero-García, Noelia; Flores-Burgess, Antonio; Ladrón de Guevara-Miranda, David; Serrano, Antonia; García-Durán, Laura; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2022-07-12)Recently, we described that Galanin(1-15)[GAL(1-15)] enhanced Escitalopram(ESC) effectiveness in depression symptoms. Moreover GAL(1-15) induces a substantial reduction in alcohol consumption. To investigate the effect of ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Puigcerver-Martínez, Araceli; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2019-06-17)Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ... -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2017)The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ... -
Galanin (1-15) enhances the behavioural effects of escitalopram in the forced swimming test in rats
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; Puigcerver-Martínez, Araceli; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Millón-Peñuela, Carmelo; Díaz-Cabiale, Zaida[et al.] (2021-01-22)The selective serotonergic reuptake inhibitors (SSRIs) are the most commonly used for the treatment of major depression. Recently, we observed that the Galanin N-terminal fragment (1-15) [GAL(1-15)] enhances the ... -
Galanin (1-15) potentiates the antidepres-sant-like effects induced by Escitalopram in a rat model of depression
García-Durán, Laura; Flores-Burgess, Antonio; Cantero-García, Noelia; Puigcerver-Martínez, Araceli; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Millón-Peñuela, Carmelo; Díaz-Cabiale, Zaida[et al.] (2021-10-07)Selective 5-HT reuptake inhibitor antidepressants (SSRIs) are the first choice in major depressive disorder (MDD), but 50% of affected patients do not show improvement. Galanin(1-15) [GAL(1-15)] enhanced Fluoxetine ... -
Galanin and galanin fragment 1-15 modulate antidepressant responses by targeting 5-HT1AR-GALR heteroreceptor complexes of the ascending midbrain serotonin pathways.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (Cinp, 2016-07-03)Mood disorders, including depression and anxiety, are among the most prevalent mental illnesses with high socioeconomic impact. Although the underlying mechanisms have not yet been clearly defined in the last decade the ...