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Mostrando ítems 21-32 de 32
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Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease.
Flores-López, María; García-Marchena, Nuria; Pavón-Morón, Francisco Javier; Lara, Estrella; Porras Perales, Óscar; Araos, Pedro; Requena-Ocaña, Nerea; Torres-Galván, Sandra; Mañas-Padilla, María del Carmen; Rubio, Gabriel; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier
; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela
; García-Fernández, María Inmaculada
; Serrano, Antonia[et al.] (2021-09-13)
Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX-LPA axis has been associated with cognitive dysfunction and inflammatory diseases, ... -
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Serrano-Castro, Pedro Jesús; Flores-López, María; García-Marchena, Nuria; Oliver-Martos, Begoña
; Ruiz-Ruiz, Juan Jesús; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Suárez-Pérez, Juan
; Rodriguez-de-Fonseca, Fernando[et al.] (IOAP-MDPI, 2023-01-07)
For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced ... -
Plasma endocannabinoid alterations as a link in the comorbidity of Alzheimer's disease and type 2 diabetes mellitus.
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús
; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan
[et al.] (2023)
Over the last several years, studies have suggested a role of endocannabinoids such as 2-AG and 2-OG in the impairment of β-cell function and insulin secretion, as well as in the control of lipid and glucose metabolism in ... -
Plasma endocannabinoids as potential biomarkers of type 2 diabetes mellitus in elderly patients with mild cognitive impairment
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús
; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan
[et al.] (Sociedad Española de Investigación sobre Cannabinoides (SEIC), 2022)
Background: Besides their role in the nervous system and the development of cognitive impairment in elderly patients, compelling evidence suggests that endocannabinoids (ECBs) are related to motivational responses in obesity ... -
¿Por qué no preguntarle a los dientes? Un estudio en difracción de RX para la estimación del intervalo postmortem.
La determinación del Intervalo Postmortem (IPM) en etapas prolongadas es difícil de estimar con precisión. El objetivo principal de este trabajo fue estudiar la existencia de una correlación entre los cambios en la ... -
¿Por qué no preguntarle a los dientes?. Un estudio en difracción de RX para la estimación del intervalo postmortem
Rubio-Lamia, Leticia Olga; Suárez-Pérez, Juan
; Santos-Amaya, Ignacio Miguel
; Martín-de-las-Heras, Stella
; Zapico, Sara C. (2022)
La determinación del intervalo postmortem (IPM) a partir de restos mineralizados es de gran interés científico, pero también tiene importantes implicaciones legales. Aunque existen varios métodos para la estimación del IPM ... -
Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency
Rubio-Lamia, Leticia Olga; Vargas, Antonio; River, Patricia; López-Gambero, Antonio J.; Tobar, Rubén; Christians, Julian K.; Martín-de-las-Heras, Stella
; Rodriguez-de-Fonseca, Fernando; Chowen, Julie A.; Argente, Jesús; Suárez-Pérez, Juan
[et al.] (MDPI, 2021)
Deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), an IGF-1 availability regulator, causes postnatal growth failure and dysregulation of bone size and density. The present study aimed to determine the effects ... -
Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
Flores-López, María; García-Marchena, Nuria; Araos Gómez, Pedro Fernando; Requena-Ocaña, Nerea; Porras-Perales, Oscar; Torres-Galván, Sandra; Suárez-Pérez, Juan; Pizarro Lozano, Nieves; De la Torre, Rafael; Rubio, Gabriel; Ruiz-Ruiz, Juan Jesús; Rodriguez-de-Fonseca, Fernando; Serrano, Antonia; Pavón-Morón, Francisco Javier[et al.] (IOAP-MPDI, 2022-04-30)
Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ... -
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Fernández-Arjona, María del Mar; Navarro, Juan Antonio; López-Gambero, Antonio J.; De Ceglia, Marialuisa; Rodríguez, Miguel; Rubio-Lamia, Leticia Olga; Rodríguez de Fonseca, Fernando; Barrios, Vicente; Chowen, Julie A.; Argente, Jesús; Rivera, Patricia; Suárez-Pérez, Juan
[et al.] (BMC Springer Nature, 2024-04-08)
Understanding the physiological role of pregnancy-associated plasma protein-A2 (PAPP-A2), a proteinase involved in the insulin-like growth factor-1 (IGF1) availability to regulate growth, could provide insight into new ... -
Spectrophotometric color measurement to assess temperature of exposure in cortical and medullar of heated human bones: a preliminary study
Rubio-Lamia, Leticia Olga; Díaz-Vico, Ramona; Smith-Fernández, Inés María
; Smith-Fernández, José Aníbal
; Suárez-Pérez, Juan
; Martín-de-las-Heras, Stella
; Santos-Amaya, Ignacio Miguel
[et al.] (2020)
Heated-bone color changes may provide information about temperature of exposure, with interest for anthropologists and forensic experts. The aim of this study was to assess heat-induced color changes by spectrophotometry ... -
Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids.
Suárez-Pérez, Juan; Romero-Zerbo, Silvana Yanina
; Márquez, Lucia; Rivera, Patricia; Iglesias, Mar; Bermúdez Silva, Francisco Javier; Andreu, Montserrat; Rodriguez-de-Fonseca, Fernando[et al.] (PLOS, 2012)
Studies in animal models and humans suggest anti-inflammatory roles on the N-acylethanolamide (NAE)-peroxisome proliferators activated receptor alpha (PPARα) system in inflammatory bowel diseases. However, the presence and ... -
Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
Requena-Ocaña, Nerea; Flores-López, María; Papaseit, Esther; García-Marchena, Nuria; Ruiz-Ruiz, Juan Jesús; Ortega-Pinazo, Jesús; Serrano, Antonia; Pavón-Morón, Francisco Javier; Farré, Magí; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Araos Gómez, Pedro Fernando[et al.] (IOAP-MPDI, 2022-04-20)
(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has ...