Listar por autor "Díaz-Cabiale, Zaida"
Mostrando ítems 21-40 de 55
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Galanin (1-15) potentiates the antidepres-sant-like effects induced by Escitalopram in a rat model of depression
García-Durán, Laura
; Flores-Burgess, Antonio; Cantero-García, Noelia; Puigcerver-Martínez, Araceli; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Millón-Peñuela, Carmelo; Díaz-Cabiale, Zaida[et al.] (2021-10-07)
Selective 5-HT reuptake inhibitor antidepressants (SSRIs) are the first choice in major depressive disorder (MDD), but 50% of affected patients do not show improvement. Galanin(1-15) [GAL(1-15)] enhanced Fluoxetine ... -
Galanin and galanin fragment 1-15 modulate antidepressant responses by targeting 5-HT1AR-GALR heteroreceptor complexes of the ascending midbrain serotonin pathways.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (Cinp, 2016-07-03)
Mood disorders, including depression and anxiety, are among the most prevalent mental illnesses with high socioeconomic impact. Although the underlying mechanisms have not yet been clearly defined in the last decade the ... -
Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-05)
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin interacts with Neuropeptide Y Y1 receptor in the dentate gyrus of the hippocampus through GALR2/NPYY1R heterodimers
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2016-07-11)
We have shown Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to analyze GAL/NPYY1R interactions ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, María Estela; Gago-Calderón, Belén; Serrano, Antonia; Sturla, Antonella; García-Durán, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2018-06-28)
Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Galanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Gago-Calderón, Belén; Parrado-Romero, Concepción; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2016-07-27)
Galanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In ... -
Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Flores-Burgess, Antonio; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Coveñas, Rafael; Santín-Núñez, Luis Javier; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2014-07-16)
Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have ... -
Galanin n-terminal fragment (1-15) induces an anxiety- and depressive-like behaviours in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-21)
Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. We have shown that intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) ... -
Galanin N-terminal fragment (1-15) reduces alcohol consumption in the self-administration with involvement of mesocorticolimbic system in rats.
Cantero-García, Noelia; Flores Gómez, Marta; Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Orio, Laura; Serrano, Antonia; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2023)
Alcohol Use Disorder (AUD) is a highly prevalent disorder characterized by an impaired ability tostop or control alcohol use despite the adverse consequences. Nowadays, AUD treatment is limiteddue to the low efficacy of ... -
Galanin N-terminal fragment (1− 15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system: dataset
Cantero-García, Noelia; Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Orio, Laura; Serrano, Antonia; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (Universidad de Málaga, 2022)
Alcohol Use Disorder (AUD) is among the most prevalent mental illnesses, and due to the low efficacy of the current medication, it is essential to find new biological targets that could modulate alcohol consumption. Since ... -
Galanin N-terminal fragment (1−15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system
Cantero-García, Noelia; Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Orio, Laura; Serrano, Antonia; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (Elsevier, 2022-09)
Alcohol Use Disorder (AUD) is among the most prevalent mental illnesses, and due to the low efficacy of the current medication, it is essential to find new biological targets that could modulate alcohol consumption. Since ... -
Galanin n-terminal gragment (1-15) modifies the 5-HT1A receptor against [H3]-8-OH-DPAT binding in the dorsal raphe and hippocampus of the rat
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Barroto-Escuela, Dasiel; Santín-Núñez, Luis Javier; Gago-Calderón, Belén; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2016-09-09)
We have described that Galanin N-terminal fragment (1-15) [GAL(1-15)] is associated with depressive effects and also modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist 8-OH-DPAT. The aim ... -
Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-05)
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin receptor/neuropeptide y recptor interactions in the central nervous system
Díaz-Cabiale, Zaida; Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo; Borroto Escuela, Dasiel Óscar; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel[et al.] (2013-11-20)
The presence of Galanin and Neuropeptide Y and/or their receptors in many relevant brain regions related to learning and memory, mood, cardiovascular control and food intake implies that Galanin, and Neuropeptide Y may ... -
Galanin(1-15) and Naltrexone: A novel approach for alcohol use disorder in rats, involving the mesolimbic system.
Flores Gómez, Marta; García-Cantero, Noelia; Pineda-Gomez, Juan Pedro; Moh-Ahmed, Amel; Flores-Burgess, Antonio; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (Elsevier, 2025-05-16)
Alcohol Use Disorder (AUD) is a highly prevalent psychiatric and represents a significant public health challenge. Naltrexone (NTX), a mu-opioid receptor antagonist widely used for AUD treatment, has limited efficacy due ... -
Galanin(1-15) enhanced the antidepressant-like effects of escitalopram in the olfactory bulbectomy rats in the forced swimming test through 5-HT1A receptors
García-Durán, Laura; Flores-Burgess, Antonio; Cantero-García, Noelia; Puigcerver-Martínez, Araceli; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Millón-Peñuela, Carmelo; Díaz-Cabiale, Zaida[et al.] (2022-07-12)
We previously described that Galanin (1-15) [GAL(1-15)] enhances the antidepressant-like effects induced by the SSRI Fluoxetine in the forced swimming test (FST) in naïve rats. In this work, we have analyzed in olfactory ... -
Galanin(1-15) reverses the impaired long-term memory effect of fluoxetine in the novel object recognition test. Role of 5-HT1A receptor in medial prefrontal cortex
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Coveñas, Rafael; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-12-16)
In this work, we have studied the effects of GAL(1-15) on FLX- mediated effects on the NOR and the OLM, two tasks where FLX treatment impaired long-term memories 24h post-training. Since the mPFC is a core region for the ... -
Galanin/ Neuropeptide Y Y1 receptor interaction at the cellular and receptor level in the amygdala
Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Díaz-Cabiale, Zaida; Narváez-Bueno, José Ángel[et al.] (2013-11-18)
Galanin (GAL) interacts functionally with Neuropeptide Y Y1 receptor (Y1) in the nucleus tractus solitarius and the arcuate nucleus. Since GAL and Y1 participate in mood disorders, the aim of this work was to analyze GAL/Y1 ... -
GALR1/GALR2 Knockdown rats block the Depression and Anxiogenic effects induced by GAL(1-15): The Heterodimer GALR1/GALR2 as a target of GAL(1-15).
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
GALR2/NPYY1R heterodimers interact at receptor level in the dentate gyrus of the hippocampus in rats
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2016-09-26)
Previously, we have described Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to study GAL/NPYY1R ...