Listar por autor "Serrano, Antonia"
Mostrando ítems 21-32 de 32
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Plasma Concentrations of High Mobility Group Box 1 Proteins and Soluble Receptors for Advanced Glycation End-Products Are Relevant Biomarkers of Cognitive Impairment in Alcohol Use Disorder: A Pilot Study.
Rodriguez-de-Fonseca, Fernando; Medina-Paz, Francisco; Sapozhnikov, Mira; Hurtado-Guerrero, Isaac; Rubio-Lamia, Leticia Olga
; Martín-de-las-Heras, Stella; Requena-Ocaña, Nerea; Flores-López, María; Fernández-Arjona, María del Mar; Rivera, Patricia; Serrano, Antonia; Serrano-Castro, Pedro Jesús; Zapico, Sara C.; Suárez-Pérez, Juan[et al.] (MDPI (Toxics), 2024)
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and ... -
Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease.
Flores-López, María; García-Marchena, Nuria; Pavón-Morón, Francisco Javier; Lara, Estrella; Porras Perales, Óscar; Araos, Pedro; Requena-Ocaña, Nerea; Torres-Galván, Sandra; Mañas-Padilla, María del Carmen; Rubio, Gabriel; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Serrano, Antonia[et al.] (2021-09-13)
Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX-LPA axis has been associated with cognitive dysfunction and inflammatory diseases, ... -
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Serrano-Castro, Pedro Jesús; Flores-López, María; García-Marchena, Nuria; Oliver-Martos, Begoña; Ruiz-Ruiz, Juan Jesús; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando[et al.] (IOAP-MDPI, 2023-01-07)
For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced ... -
Reduction of adult hippocampal neurogenesis modifies brain functional connectivity and enhances cocaine-seeking in mice
Castilla-Ortega, María Estela; Ladrón de Guevara-Miranda, David; Blanco-Calvo, Eduardo; Serrano, Antonia; Pedraz, María; Estivill-Torrús, Guillermo; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier[et al.] (2015-09-16)
Recently, adult hippocampal neurogenesis has been proposed as a putative neuroplastic mechanism involved in those behavioural processes. In this work, we studied the effect of the inhibition of adult hippocampal neurogenesis ... -
Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
Flores-López, María; García-Marchena, Nuria; Araos Gómez, Pedro Fernando; Requena-Ocaña, Nerea; Porras-Perales, Oscar; Torres-Galván, Sandra; Suárez-Pérez, Juan; Pizarro Lozano, Nieves; De la Torre, Rafael; Rubio, Gabriel; Ruiz-Ruiz, Juan Jesús; Rodriguez-de-Fonseca, Fernando; Serrano, Antonia; Pavón-Morón, Francisco Javier[et al.] (IOAP-MPDI, 2022-04-30)
Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ... -
Sex-specific alterations in emotional behavior and neurotransmitter systems in LPA1 receptor-deficient mice
Sánchez-Marín, Laura; Jiménez-Castilla, Violeta; Flores-López, María; Navarro Galera, Juan Antonio; Gavito, Ana Luisa; Blanco-Calvo, Eduardo; Santín-Núñez, Luis Javier; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Serrano, Antonia[et al.] (Elsevier, 2025-01-24)
Lysophosphatidic acid (LPA) and the endocannabinoid system (ECS) are critical lipid signaling pathways involved in emotional regulation and behavior. Despite their interconnected roles and shared metabolic pathways, the ... -
Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior
Sánchez-Marín, Laura; Ladrón de Guevara-Miranda, David; Mañas-Padilla, María del Carmen; Alén, Francisco; Moreno-Fernández, Román D.; Díaz-Navarro, Caridad; Pérez-del Palacio, José; García-Fernández, María Inmaculada; Pedraza-Benítez, María del Carmen; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín-Núñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (Elsevier, 2018-05-01)
The systemic administration of lysophosphatidic acid (LPA) LPA1/3 receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA1 receptor-null mice engage in increased ... -
The combination of Galanin (1-15) and Escitalopram decrease the alcohol selfadministration in rats through the functional network ventral tegmental area – dorsal raphe.
Flores Gómez, Marta; García-Cantero, Noelia; Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Serrano, Antonia; Orio, Laura; Puigcerver-Martínez, Araceli; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2023)
Alcohol Use Disorder AUD is a highly prevalent, and most AUD patients suffer comorbidity with depression. To investigate the effect of GAL(1-15) on ESCmediated effect in depression-alcoholism comorbidity, we used the alcohol ... -
The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression
Cantero-García, Noelia; Flores-Burgess, Antonio; Ladrón de Guevara-Miranda, David; Serrano, Antonia; García-Durán, Laura; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (Universidad de Málaga, 2022-07-25)
Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical ... -
The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder
(Elsevier, 2017-10-01)After discovering that addictive drugs alter adult neurogenesis, the potential role of adult-born hippocampal neurons in drug addiction has become a promising research field, in which cocaine is the most frequently ... -
Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
Requena-Ocaña, Nerea; Flores-López, María; Papaseit, Esther; García-Marchena, Nuria; Ruiz-Ruiz, Juan Jesús; Ortega-Pinazo, Jesús; Serrano, Antonia; Pavón-Morón, Francisco Javier; Farré, Magí; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Araos Gómez, Pedro Fernando[et al.] (IOAP-MPDI, 2022-04-20)
(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has ...