Listar por departamento/instituto "Biología Celular, Genética y Fisiología"
Mostrando ítems 21-40 de 652
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A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
Visser, Rick
; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (2013-11-27)
RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi
Rosas Díaz; Dan, Zhanga; Fan, Pengfei; Liping, Wang; Xue, Ding; Yuli, Jiang; Jiménez-Góngora, Tamara; Medina-Puche, Laura; Xinyan, Zhao; Zhengyan, Feng; Guiping, Zhang; Xiaokun, Liuc; Rodríguez-Bejarano, Eduardo; Li, Tana; Heng, Zhang; Jian-Kang, Zhua; Weiman, Xinga; Faulkner, Christine; Shingo, Nagawa; Lozano Durán, Rosa[et al.] (PNAS, 2018-01-23)
RNA interference (RNAi) in plants can move from cell to cell, allowing for systemic spread of an antiviral immune response. How this cell-to-cell spread of silencing is regulated is currently unknown. Here, we describe ... -
Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai-Amal, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Absence of LPA1 signaling results in defective cortical development
Estivill-Torrús, Guillermo; Llebrez Zayas, Pedro; Matas-Rico, Elisa; Rodríguez de Fonseca, Fernando; Chun, Jerold; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen; De-Diego-Barbado, Isabel; Del Arco-Herrera, Ignacio; Fernández-Llebrez, Pedro[et al.] (Oxford academy, 2008-04)
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing ... -
Acciones neuroprotectoras del estradiol y los receptores de estrógenos
(2016-11-07)El estradiol y la progesterona regulan el desarrollo y la función de los sistemas nerviosos central y periférico. Además, las hormonas ováricas, actuando a través de las células endoteliales, las células de glía y las ... -
Activation of caspase-3 pathway by expression of sGαi2 protein in BHK cells.
López-Aranda, Manuel Francisco; Navarro-Lobato, Irene; López-Téllez, Juan Félix; Blanco-Calvo, Eduardo; Masmudi-Martín, Mariam; Khan, Zafaruddin[et al.] (Elsevier, 2008)
Treatment with dopamine and other dopamine D2 receptor agonists has been shown to induce cell death through activation of caspase-3 pathway. However, initial step that leads to the activation of caspase-3 in D2 receptor-mediated ... -
Activation of the JAK-STAT Signaling Pathway after In Vitro Stimulation with IFN beta in Multiple Sclerosis Patients According to the Therapeutic Response to IFN beta
Hurtado-Guerrero, Isaac; Pinto-Medel, María-Jesús; Urbaneja, Patricia; Rodríguez-Bada, José Luis; León, Antonio; Guerrero, Miguel; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Public Library of Science, 2017)
Interferon beta (IFNß) is a common treatment used for multiple sclerosis (MS) which acts through the activation of the JAK-STAT pathway. However, this therapy is not always effective and currently there are no reliable ... -
Actividad antagonista de aislados del Virus de la Septicemia Hemorrágica Viral (VHSV) frente al sistema del interferón tipo I de lenguado senegalés
Gémez-Mata, Juan; Álvarez-Torres, Daniel; García-Rosado, Esther; Alonso-Sánchez, María del Carmen; Béjar-Alvarado, Julia (2017-10-11)
Senegalese sole (Solea senegalensis) is susceptible to marine Viral Haemorrhagic Septicaemia Virus (VHSV) isolates, but it is not affected by freshwater VHSV isolates. In addition, the sole type I interferon (IFN I) response ... -
Actividad inmunomoduladora y antiviral del Propil Propano Tiosulfinato, un compuesto derivado de la cebolla, frente a betanodavirus
Moreno, Patricia; Baños-Arjona, Alberto; Alonso-Sánchez, María del Carmen; García-Rosado, Esther; Béjar-Alvarado, Julia (2022-11)
Los compuestos organosulfurados de las especies del género Allium, como el PropilPropano Tiosulfinato (PTS), se utilizan como aditivos funcionales en alimentación animal por sus propiedades antimicrobianas. Sin embargo, ... -
Adipogenic Impairment of Adipose Tissue-Derived Mesenchymal Stem Cells in Subjects With Metabolic Syndrome: Possible Protective Role of FGF2
Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Lhamyani, Said; Clemente-Postigo, María Mercedes; Alcaide Torres, Juan; Bernal-López, María Rosa; El-Bekay, Rajaa; Tinahones-Madueño, Francisco José[et al.] (Endocrine Society, 2017)
Context: The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome. Objetive: The aim of this study was to examine the state of adipose tissue-derived ... -
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura Isabel; García-Fuentes, Eduardo; Andreo-López, Juana; Sánchez-Varo, Raquel María; Gómez-Mediavilla, Ángela; López, Manuela G.; Gutiérrez, Antonia; Baglietto-Vargas, David; Garrido-Sánchez, Lourdes; García-Caballero, Melissa[et al.] (Wiley, 2023-09-01)
Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates ... -
Adipose tissue gene expression of factors related to lipid processing in obesity
Clemente-Postigo, María Mercedes; Queipo Ortuño, María Isabel; Fernandez-García, Diego; Gómez-Huelgas, Ricardo; Tinahones, Francisco J; Cardona, Fernando[et al.] (PLOS One, 2011)
Background Adipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is the first step to adipose tissue lipid ... -
Adipose tissue inflammation and VDR expression and methylation in colorectal cancer
Castellano-Castillo, Daniel; Morcillo Espina, Sonsoles; Clemente-Postigo, María Mercedes; Crujeiras Martínez, Ana Belén; Fernández-García, José Carlos; Torres Sánchez, Esperanza; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (BMC (Part of Springer Nature), 2018)
Background: Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. ... -
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
Aggregate-Depleted Brain Fails to Induce Ab Deposition in a Mouse Model of Alzheimer’s Disease.
(PLOS, 2014-02-12)Recent studies in animal models of Alzheimer’s disease (AD) show that amyloid-beta (Ab) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this ... -
Allelic variation in the indoleacetic acid-lysine synthase gene of the bacterial pathogen Pseudomonas savastanoi and its role in auxin production
Pintado Calvillo, Adrián; Domínguez Cerván, Hilario; Pastor, Victoria; Vincent, Marissa; Goo Lee, Soon; Flors, Víctor; Ramos-Rodríguez, Cayo Juan[et al.] (Frontiers Media, 2023-06-06)
Indole-3-acetic acid (IAA) production is a pathogenicity/virulence factor in the Pseudomonas syringae complex, including Pseudomonas savastanoi. P. savastanoi pathovars (pvs.) genomes contain the iaaL gene, encoding an ... -
Alteraciones del perfil epitranscriptómico (m6A) asociadas a mecanismos biológicos del cáncer colorrectal y obesidad.
(2023-11-24)La obesidad considerada un factor de riesgo crucial en el inicio y progresión del cáncer colorrectal, podría promover un microentorno favorable a la carcinogénesis mediado por alteraciones epitranscriptómicas, como la ... -
Amyloid propagation in a sporadic model of Alzheimer disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; Cheung, Alwin; Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2021-11-04)
Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ...