Listar por departamento/instituto "Biología Molecular y Bioquímica"
Mostrando ítems 1-20 de 585
-
A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Carbonell-Ballesteros, Max; Durán-Nebreda, Salva; Montañez, Raúl; Macía, Javier; Rodríguez-Caso, Carlos Francisco
(Oxfrod University Press, 2014-12-16)
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly ... -
A central role for bifunctional aspartate/prephenate aminotransferase in the biosynthesis of amino acids in plant plastids.
El-Azaz-Ciudad, Jorge; Cánovas-Ramos, Francisco Miguel; De-la-Torre-Fazio, Fernando Nicolás; Ávila-Sáez, Concepción (2014-06-27)
A central role for bifunctional aspartate/prephenate aminotransferase in the biosynthesis of amino acids in plant plastids. Fernando de la Torre, Jorge El-Azaz, Concepción Ávila, Francisco M. Cánovas Departamento de ... -
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
(SAGE Publications, 2014-01-28)The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microarrays to ... -
A course-based undergraduate research experience to illustrate the early stages of the drug discovery process
García-Caballero, Melissa; Moya-García, Aurelio Ángel; Torres-Vargas, José Antonio; García-Ponce, Ángel Luis; Rodríguez-Quesada, Ana María (Wiley, 2022-07-12)
We have implemented at the University of Málaga (Spain) a new course-based undergraduate research experience (CURE) to involve undergraduate students of Science in a real-world scientific problem. Within the topic “Let's ... -
A development of chimeric VEGFR2 TK inhibitor based on two ligand conformers from PDB: 1Y6A complex--medicinal chemistry consequences of a TKs analysis
Lintnerová, Lucia; García-Caballero, Melissa; Fridrich, Gregáň; Melicherčík, Milan; Rodríguez-Quesada, Ana María; Dobiaš, Juraj; Lác, Ján; Sališová, Marta; Boháč, Andrej[et al.] (Elsevier, 2014-01-24)
El VEGFR2 es un importante mediador de la angiogénesis e influye en el destino de algunas células madre cancerosas. Aquí analizamos las 34 estructuras de VEGFR2 TK disponibles en la base de datos PDB. De ellas, un complejo ... -
A morphospace for synthetic organs and organoids: the possible and the actual.
(Oxford University Press, 2016)Efforts in evolutionary developmental biology have shed light on how organs are developed and why evolution has selected some structures instead of others. These advances in the understanding of organogenesis along with ... -
A network biology approach to novel therapeutic estrategies
(2017-05-30)Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the ... -
A novel eIF4E-interacting protein that forms non-canonical translation initiation complexes
(Nature Research, 2019-12)Translation is a fundamental step in gene expression that regulates multiple developmental and stress responses. One key step of translation initiation is the association between eIF4E and eIF4G. This process is regulated ... -
A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.
Marrero Capitán, Ana Dácil; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Cárdenas, Casimiro (MDPI, 2023-07-27)
Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic uses and pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves recently allowed ... -
A revised view on the evolution of glutamine synthetase isoenzymes in plants
Valderrama-Martín, José Miguel; Ortigosa Peña, Francisco; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Hirel, Bertrand; Cantón, Francisco R.; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2022-02)
Glutamine synthetase (GS) is a key enzyme responsible for the incorporation of inorganic nitrogen in the form of ammonium into the amino acid glutamine. In plants, two groups of functional GS enzymes are found: eubacterial ... -
A role for antizyme inhibitor 2 in the biosynthesis and content of histamine and serotonin in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Peñafiel, Rafael; Fajardo-Paredes, Ignacio José[et al.] (2015-09-14)
Polyamines (putrescine, spermidine and spermine; PAs) are required for the survival of the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine ... -
A role for antizyme inhibitor 2 in the biosynthesis and content of serotonin and histamine in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Peñafiel, Rafael; Fajardo-Paredes, Ignacio José[et al.] (2015-09-04)
Polyamines (putrescine, spermidine and spermine; PAs) are essential for the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase and PA ... -
A workflow with dedicated tools for preparing reference transcriptomes from non-model organisms has evidenced important biological information
Claros-Díaz, Manuel Gonzalo; Benzekri, Hicham; Seoane, Pedro; Carmona Muñoz, Rosario Maria; Bautista-Moreno, Rocío; Guerrero-Fernández, Darío; Fernández-Pozo, Noé[et al.] (2014-10-01)
Construction transcriptomes of non-model organisms is a common task nowadays due to the advent of low-cost sequencing platforms. The non-model organisms require a de novo assembling strategy since no reference is available. ... -
Abiotic stresses differentially affect the expression of O-methyltransferase genes related to methoxypyrazine biosynthesis in seeded and parthenocarpic fruits of Vitis vinifera (L.)
(Elsevier, 2014-01-08)MPs (3-alkyl-2-methoxypyrazines) are grape-derived aroma compounds that are associated with detrimental herbaceous flavours in some wines. It is well known that several viticultural and environmental parameters can modulate ... -
Abordaje desde la prevención primaria, secundaria y terciaria de las infecciones de transmisión sexual en adolescentes y adultos jóvenes del distrito costa del sol
(UMA Editorial, 2024)Las infecciones de transmisión sexual han aumentado globalmente en los últimos años, especialmente entre los jóvenes, y pueden conducir a procesos graves. Su prevención, diagnóstico precoz y tratamiento adecuado son ... -
Abordaje integral de los errores en la fase preanalítica.
Romero-Ruiz, Adolfo (UMA Editorial, 2024)
Se puede definir la fase preanalítica del proceso laboratorio como aquella que da comienzo cuando se realiza la petición analítica y finaliza cuando la muestra, ya preparada, es entregada en el laboratorio. En nuestro ... -
Actividad del Sistema Renina-Angiotensina en relación con sus polimorfismos genéticos
(Servicio de Publicaciones y Divulgación Científica, 2000)La realización del presente estudio sobre sujetos jóvenes y sanos no hipertensos tiene dos objetivos primordiales: El primero es analizar la relación de los polimorfismos de los genes del Sistema Renina-Angiotensina, el ... -
AD0157, a pyrrolidinedione fungal metabolite, inhibits angiogenesis by targeting the Akt signaling pathway
García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2014-09-16)
In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of ... -
Adaptative mechanisms of cellulose synthesis under stress conditions
Pagano Márquez, Raquel; Macho, Alberto P.; Castillo-Garriga, Araceli; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel (2023-07-09)
Cellulose is the main structural compound of the plant cell wall and the most abundant biopolymer on Earth (Bar‐On et al 2018). The essential role of cellulose in plant development and defence highlights the importance ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ...