Listar por departamento/instituto "Química Orgánica"
Mostrando ítems 1-20 de 165
-
A Peptide/Fullerene Hybrid for Multivalent Recognition of E-Selectin
(2022-06-28)Molecular recognition through ligand-receptor interactions is a very important mechanism for metastatic processes. Among all of them, multivalent protein-carbohydrate interactions play a fundamental role in tumor ... -
A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells.
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio
; Pearson, John; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Perez-Inestrosa, Ezequiel[et al.] (Elsevier, 2019)
The detection of reactive oxygen species (ROS) in biological systems and its imaging is of great importance. Among them, the hydroxyl radical (radical dotOH) stands out as one of the most reactive, playing an important ... -
Adsorbatos isoquinolínicos y benzazepínicos: síntesis e incorporación a superficies de silicio y nanopartículas
(UMA Editorial, 2019)La mayoría de los productos farmacéuticos aprobados por la FDA presentan en su estructura átomos de nitrógeno. De hecho, más de la mitad de ellos incluyen un heterociclo de nitrógeno. Entre los heterociclos de nitrógeno ... -
Allergic reactions to β-lactam antibiotics: chemical approaches for improving in vitro diagnosis
(UMA Editorial, 2018-10-16)Drug hypersensitivity reactions are a significant public health problem with important consequences on patient health and healthcare costs. It has been reported that only a low percentage of initial cases suspected of ... -
Aminonaphtamiline-squaraine dyad: photophysical properties and bioimaging application
Collado-Martín, Daniel (2018-09-19)
Squaraines is an important part of the cyanine family which have high extinction coefficients, sharp absorption bands, and intense fluorescence spectra in the red and near infrared region in solution.[1] The unique electronic ... -
Aminonaphthalimide-squaraine dyads: photophysical properties and bioimaging application
Squaraines is an important part of the cyanine family which have high extinction coefficients, sharp absorption bands, and intense fluorescence spectra in the red and near infrared region in solution.[1] The unique electronic ... -
Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel; González Morena, Juan Manuel; Sanchez Gomez, Francisco J; Salas, María; Montañez-Vega, María Isabel; Altomare, Alessandra; Aldini, Giancarlo; Pajares, Maria Angeles; Pérez-Sala, Dolores[et al.] (Frontiers, 2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.
Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Valeriote, Frederick A.; Sarabia-García, Francisco Ramón (Chemistry Europe · European Chemical Societies Publishing, 2013-03-19)
Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with ... -
An olefin cross-metathesis approach to depudecin and stereoisomeric analogues
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Guerrero Vásquez, Guillermo A.; Sarabia-García, Francisco Ramón (ACS, 2017)
A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, ... -
An olefin metathesis approach towards the solomonamides.
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Sarabia-García, Francisco Ramón (Elsevier, 2016)
A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these ... -
Asymmetric total synthesis of alkaloid natural products without external chiral sources
(2018-03-22)The chirality of a starting material having a chiral sp3-carbon can be preserved under some circumstances in the reaction product even though the reaction proceeds at the chiral carbon as a reaction center through reactive ... -
Azoles
Collado-Martín, Daniel (2014-03-24)
Azoles. Imidazol, tiazoles y oxazoles: reactividad y síntesis. Pirazol, isoozaxol, isotiazol: reactividad y síntesis. -
Back to the Future - The Scientific Exploration of An Ancient Medicinal Plant
(2016-10-13)Alkaloids are active compounds found in plants. In the conference has been reviewed new sceletium alkaloids isolated from african plants. -
Bengamide Analogues Show a Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study
García-Pinel, Beatriz; Porras Alcalá, Cristina; Cabeza, Laura; Ortiz, Raul; Prados, José; Melguizo, Consolación; Cheng-Sánchez, Iván; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón[et al.] (2020-05-02)
The limited success and side effects of the current chemotherapeutic strategies against colorectal cancer (CRC), the third most common cancer worldwide, demand an assay with new drugs. The prominent antitumor activities ... -
Benzotriazole-based multidonor-acceptor systems as attractive two-photon absorption dye platforms
Benítez-Martín, Carlos; Donoso, Beatriz; Torres-Moya, Ivan; Herrera-Imbroda, Jesús; Díaz-Ortiz, Ángel; Nájera-Albendín, Francisco; Prieto, Pilar; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (Elsevier, 2022-02-03)
Pyrazine-decorated benzotriazole cores allow the orthogonal combination of two dipolar systems within a single molecule. A series of this type of derivatives was synthesized and their photophysical features were studied. ... -
Biciclos condensados de compuestos heterocíclicos aromáticos de cinco eslabones.
Collado-Martín, Daniel (2014-03-11)
Indol: Propiedades. Reactividad química: SEAr, SNAr. Reacciones de metalación. Derivados importantes de pirrol. Síntesis de pirrol. Otros heterociclos: benzo[b]furanos y benzo[b]tiofenos. Isoindol. -
Carbazole-based Diradicals for Dynamic Covalent Chemistry
Ruiz-Delgado, María del Carmen; Hartl, Frantisek; Li, Hongxiang; Sancho-García, Juan C.; Pérez Guardiola, Andrés; Rodríguez-González, Sandra; López-Navarrete, Juan Teodomiro; Hernández-Jolín, Víctor; Badía-Domínguez, María Irene[et al.] (2020-01-29)
Dynamic covalent chemistry (DCC) is focused on the creation of structural scaffolds based on chemical components that interact through strong but reversible bonds. In fact, dynamic covalent bonds receive lot of attention ... -
Catalyzed Methods to Synthesize Pyrimidine and Related Heterocyclic Compounds
Díaz-Fernández, Marcos; Calvo-Losada, Saturnino; Quirante-Sánchez, José Joaquín; Sarabia-García, Francisco Ramón; Algarra-González, Manuel; Pino-González, María Soledad[et al.] (MDPI, 2023-01-12)
This review covers articles published in the period from 2010 to mid-2022 on synthetic advances in the formation of pyrimidine and related heterocyclic compounds. Special emphasis has been given to the different types ... -
Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges
García-Ruiz, Cristina; Sarabia-García, Francisco Ramón (MDPI, 2014)
Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures ... -
Combinando enzimas y complejos organometálicos: nuevos biohibridos como catalizadores altamente eficientes
(2019-01-21)Los catalizadores de metales de transición y las enzimas poseen propiedades únicas y a menudo complementarias que los han convertido en herramientas importantes para la síntesis química. La combinación de un complejo ...