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dc.contributor.authorHerrera Acosta, Enrique
dc.contributor.authorLopez, Norberto
dc.contributor.authorMartin, Modesto
dc.contributor.authorHerrera-Ceballos, Enrique
dc.date.accessioned2015-07-17T08:58:18Z
dc.date.available2015-07-17T08:58:18Z
dc.date.created2015
dc.date.issued2015-07-17
dc.identifier.urihttp://hdl.handle.net/10630/10099
dc.description.abstractBackground:Rosai-Dorfman also known as sinus histiocytosis with massive lymphadenopathy is a benign, idiopathic lymphoproliferative disorder that usually affects the lymph nodes. Cutaneous Rosai-Dorfman disease is a rare extranodal variant that occurs as histiocyte-rich inflammatory infiltrates, manifesting with a variable clinical morphology. Usually it appears as erythematous to brown papules, plaques, or nodules, with no predilection for site. The histological picture shows abnormal lymph node architecture, reactive germinal centers, fibrosis and emperipolesis in the dermis. On immunophenotypic analysis, S100 protein and CD68 are usually present on dendritic cells. Case Report: We report a case of purely cutaneous Rosai-Dorfman disease. A 55-year-old male presented to our clinic for an indurated nodule on the left malar region. He reported a slow and progressive growth of 2-year history without systemic symptoms. A cutaneous biopsy showed a nodular inflammatory infiltrate within the dermis consisting of histiocytes, local aggregates of plasma cells and lymphocytes. Histiocytes were enlarged with vesicular nuclei, and emperipolesis was observed. Furthermore, histiocytes stained positively for S-100 and CD68. Owing to local involvement, the patient received a surgery to exsect the lesion completely. Conclusions: Sinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. The diagnosis of cutaneous RDD is differentiated from other histiocytic conditions by the combination of clinical findings accompanied by histopathologic and immunohistochemical confirmationes_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isospaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectReticuloendoteliosises_ES
dc.subject.otherRosai-Dorfman dieseasees_ES
dc.subject.otherHistiocytosises_ES
dc.titleIsolated cutaneous Rosai-Dorfman disease: a case reportes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleThe 23rd World Congress of Dermatologyes_ES
dc.relation.eventplaceVancouver (Canada)es_ES
dc.relation.eventdate8-6-2015es_ES
dc.cclicenseby-nc-ndes_ES


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