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dc.contributor.authorPedraza-Sánchez-López, J.
dc.contributor.authorCastilla-Ortega, Estela
dc.contributor.authorRosell-Valle, Cristina
dc.contributor.authorMoreno-Fernández, Román D.
dc.contributor.authorZambrana-Infantes, Emma
dc.contributor.authorGarcía-Fernández, Maria Inmaculada 
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorChun, J.
dc.contributor.authorEstivill-Torrús, Guillermo
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.date.accessioned2015-07-24T11:50:30Z
dc.date.available2015-07-24T11:50:30Z
dc.date.created2015
dc.date.issued2015-07-24
dc.identifier.urihttp://hdl.handle.net/10630/10153
dc.description.abstractThe LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been proposed that this receptor has a role in controlling anxiety-like behaviours and in the detrimental consequences of stress. In general, the neurobiological mechanism of fear extinction is strikingly similar to that of the adaptative stress response (distress regulation), sharing similar neuroanatomical, neuroendocrine, and neurochemical basis. Inadequate control of the stress response could precipitate or provoke anxiety disorders. In this context, we tried to elucidate the LPA1 receptor involvement in emotional regulation. For this purpose, we first examined fear extinction, a type of emotional regulation, in normal wild-type (wt) and maLPA1-null mice using two different extinction procedures (cued fear extinction and contextual fear extinction). Additionally, to study the role of the LPA1 receptor in the absence of developmental abnormalities induced by its permanent loss, the effect of the LPA1 antagonist Ki16425 administration was examined in contextual fear extinction on wild-type mice. Next, we studied the consequences of the absence of the LPA1 receptor in two key areas involved in emotional regulation, characterizing the structure and GABAergic composition of the medial prefrontal cortex (mPFC) and the amygdala by immunohistochemical detection of neuron specific nuclear protein (NeuN), GABA-positive cells and calcium-binding proteins (calretinin (CR), parvalbumin (PV), and calbindin (CB)). Lastly, we examined the corticosterone response and the expression of a marker of neuronal activity, c-Fos protein, in the amygdala and the mPFC after acute stress. Our results revealed that lack of the LPA1-receptor induces exaggerated amygdala reactivity and endocrine responses to emotional stimuli (e.g., an acute episode of stress), revealing a role of the LPA1 receptor in regulating emotional-like behaviours. Considering that a reduction of GABAergic inhibitory control in the amygdala may be a common mechanism to generate a heightened emotional state, the abnormal emotional response reported in LPA1-null mice could be explained, at least in part, by a significant reduction of GABAérgic composition of the amygdala observed in these animals. Taking together, the LPA1 receptor is involved in emotional behaviours and in the anatomical integrity of the corticolimbic circuit, the deregulation of which may be a susceptibility factor for anxiety disorders and a potential therapeutic target for the treatment of these diseases.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectEmocioneses_ES
dc.subjectAnsiedades_ES
dc.subject.otherLPA1 receptores_ES
dc.subject.otherAnxietyes_ES
dc.subject.otherEmotional behavioures_ES
dc.titleWhat role does the LPA1 receptor play in regulating emotional-like behaviours?es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicologíaes_ES
dc.relation.eventtitleI IInternational Congress of Psychobiologyes_ES
dc.relation.eventplaceOviedoes_ES
dc.relation.eventdateJulio 2015es_ES
dc.cclicenseby-nc-ndes_ES


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