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dc.contributor.authorPérez-Martín, Margarita 
dc.contributor.authorCifuentes, Manuel 
dc.contributor.authorGrondona, Jesús M
dc.contributor.authorLópez-Ávalos, María Dolores 
dc.contributor.authorFernández-Llebrez, Pedro 
dc.date.accessioned2015-09-15T06:59:43Z
dc.date.available2015-09-15T06:59:43Z
dc.date.created2015
dc.date.issued2015-09-15
dc.identifier.urihttp://hdl.handle.net/10630/10248
dc.description.abstractNeurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. We report that, after intracerebroventricular treatment with insulin-like growth factor I (IGF-I), cell proliferation significantly increased in both the periventricular and the parenchymal zones of the whole hypothalamus. Proliferation was particularly abundant in a distinct periventricular zone of the caudal hypothalamus. This is an overlapping zone of transition, between the cubic ciliated ependymal, dorsally located, and the tanycytic ependyma, ventrally located, where three cell layers can be found: ciliated ependyma, subependyma and underlying tanycytes. After IGF-I treatment, proliferating cells were seen in the subependyma and in the layer of tanycytes. Neurons, astrocytes, tanycytes, microglia and endothelial cells of the local vessels were stained with the proliferative marker 5-bromo-2'-deoxyuridine (BrdU) in response to IGF-I. However, we never observed BrdU-positive ciliated cubic ependymal cells. In the subependyma, proliferating glial fibrillary acidic protein-positive astrocytes contacted the ventricle by an apical process bearing a single cilium and there were many labyrinthine extensions of the periventricular basement membranes. Both features are typical of neurogenic niches in other brain zones, suggesting that the central overlapping zone of the rat hypothalamic wall could be considered a neurogenic niche in response to IGF-I. These effects will be compared with those obtained for other factors.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeurobiología del desarrolloes_ES
dc.subject.otherAdult neurogenesises_ES
dc.subject.otherHypothalamuses_ES
dc.subject.otherIGF-Ies_ES
dc.subject.otherTanycyteses_ES
dc.titleIGF-I stimulates cell proliferation in a specific area of the hypothalamic walles_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleXII European Meeting on Glial Cells in Health and Diseasees_ES
dc.relation.eventplaceBilbaoes_ES
dc.relation.eventdateJulio 2015es_ES
dc.cclicenseby-nc-ndes_ES


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