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dc.contributor.authorGarcía-Vilas, J.A.
dc.contributor.authorQuesada, A.R.
dc.contributor.authorMedina, Miguel Ángel 
dc.date.accessioned2015-09-30T08:06:52Z
dc.date.available2015-09-30T08:06:52Z
dc.date.created2015
dc.date.issued2015-09-30
dc.identifier.urihttp://hdl.handle.net/10630/10362
dc.description.abstractSolid cancers have several common characteristics that Hanahan & Weinberg named as the hallmarks of cancer. Angiogenesis is an essential hallmark of cancer because tumor cells need oxygen and nutrients delivered by the vascular system. In fact, tumor growth and metastasis are angiogenesis dependent, and microvascular endothelial cells recruited by tumors have become an important target in cancer therapy. Combinations of drugs with different modes of action may lead to enhanced antitumor and antiangiogenic effects without injuring the host. The combined use of two drugs may sometimes produce enhanced, unchanged or diminished effects in comparison with their individual effects. These three different types of behaviour of the interacting drugs are called synergy, additive/indifferent and antagonistic effects. In the present work, we analyze 105 paired combinations of 15 compounds, some described by our research group as potent antiangiogenic compounds, and others currently used in clinical therapy. Our results show synergistic effects of several paired combinations using the MTT assay. [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)].This communication has the support of a travel grant "Universidad de Málaga.Campus de Excelencia Internacional Andalucía Tech".es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeovascularizaciónes_ES
dc.subjectCánceres_ES
dc.subject.otherSynergyes_ES
dc.subject.otherAngiogenesises_ES
dc.titleScreening of Synergic Interactions of Anti-Angiogenic and Anti-Tumor Compoundses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleBasel Life Science Week 2015es_ES
dc.relation.eventplaceBasilea (Suiza)es_ES
dc.relation.eventdate21/24-09-2015es_ES
dc.identifier.orcidhttp://orcid.org/0000-0001-7275-6462es_ES
dc.cclicenseby-nc-ndes_ES


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