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dc.contributor.authorFernández, M.C.
dc.contributor.authorMoncayo-Arlandi, Javier
dc.contributor.authorSoto, M. Teresa
dc.contributor.authorLópez-Unzu, Miguel A.
dc.contributor.authorFernández, Borja
dc.contributor.authorDurán, Ana C.
dc.date.accessioned2015-11-25T13:37:50Z
dc.date.available2015-11-25T13:37:50Z
dc.date.issued2015-11
dc.identifier.citationLab Anim 49 (S3) 2015: 61 (ID:61)es_ES
dc.identifier.urihttp://hdl.handle.net/10630/10728
dc.description.abstractEffect of hyperlipidic diets on normal and abnormal aortic valves in the Syrian hamster: A preliminary study. MC Fernández 1,2, J Moncayo-Arlandi 1, MT Soto 1, MA López-Unzu 1, B Fernández 1,2 and AC Durán 1,2. 1 Department of Animal Biology, Faculty of Science, University of Málaga, Spain. 2 Biomedical Research Institute of Málaga (IBIMA), University of Málaga, Spain. Bicuspid aortic valve (BAV) is the most frequent human congenital cardiac malformation. It frequently becomes stenotic due to calcification by an atherosclerosis-like process. Hyperlipidic diets have been classically used to induce atherosclerosis in laboratory animals, including Syrian hamsters. The aim here is to evaluate the effect of hyperlipidic diets in hamsters having different incidence of BAVs. We used a unique inbred strain of Syrian hamsters with a high ( 40%) incidence of spontaneous BAV, morphologically similar to that in man, another inbred strain with a low ( 4%) incidence of BAV, and an outbred, second control line, acquired from Charles River Laboratories. Three experimental groups were fed with standard diet supplemented with 2% cholesterol plus 15% butter during five months. In parallel, three control groups were fed with unmodified standard diet. Hyperlipidic diets induced lesions in the aortic valve and ascending aortic wall, i.e. subendothelial lipid deposits, valve sclerosis, and neo-intima in the aorta. We performed a preliminary, qualitative, comparative study of the lesions associated with the different animal populations and valvular phenotypes. Our results indicate that (1) the type and severity of the lesions varied among the three hamster populations, suggesting that genetic factors may be involved; (2) the aortic valve morphology seems not to determine the severity of the valvular lesions. We conclude that our hamster strain with high incidence of BAV is a promising animal model for studies on human aortic stenosis. This work was supported by P10-CTS-6068.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Andalucía Tech. P10-CTS-6068.es_ES
dc.language.isoenges_ES
dc.publisherSAGE Publications Press Ldtes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCorazón - Enfermedades - Dietoterapiaes_ES
dc.subjectAnimales de laboratorio
dc.titleEffect of hyperlipidic diets on normal and abnormal aortic valves in the Syrian hamster: A preliminary studyes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleI Iberian Congress for Laboratory Animal Science (XIII Congreso SECAL – III Congresso SPCAL)es_ES
dc.relation.eventplaceCáceres, Españaes_ES
dc.relation.eventdate18-20.11.2015es_ES
dc.identifier.orcidhttps://orcid.org/0000-0002-3293-9384es_ES
dc.cclicenseby-nc-ndes_ES


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