Mostrar el registro sencillo del ítem

dc.contributor.authorFernández, M. Carmen
dc.contributor.authorLópez-García, Alejandro
dc.contributor.authorSoto, M. Teresa
dc.contributor.authorDurán, Ana Carmen
dc.contributor.authorFernández, B
dc.date.accessioned2015-11-26T08:02:39Z
dc.date.available2015-11-26T08:02:39Z
dc.date.issued2015
dc.identifier.citationLab Anim 49 (S3) 2015: 61 (ID:63)es_ES
dc.identifier.urihttp://hdl.handle.net/10630/10729
dc.description.abstractIncidence and type of bicuspid aortic valve in two model species. MC Fernández 1,2, A López-García 1,2, MT Soto 1, AC Durán 1,2 and B Fernández 1,2. 1 Department of Animal Biology, Faculty of Science, University of Málaga, Spain. 2 Biomedical Research Institute of Málaga (IBIMA), University of Málaga, Spain. Bicuspid aortic valve (BAV) is the most frequent human congenital cardiac malformation, with an incidence of 1–2% worldwide. Two morphological types exist: type A (incidence 0.75–1.25%) and type B (incidence 0.25–0.5%), each with a distinct aetiology and natural history. Currently, ten animal models of BAV have been described in two different rodent species: one spontaneous Syrian hamster (Mesocricetus auratus) model of BAV type A and nine mutant laboratory mouse (Mus musculus) models of BAV type B. It remains to be elucidated whether the mutations leading to BAV in these models are typespecific or whether there are inter-specific differences regarding the type of BAV that hamsters, mice and humans may develop. To solve this issue, we have characterized the incidence and types of BAVs in four inbred, two outbred and two hybrid lines of Syrian hamsters (n=4,340) and in three inbred, three outbred and one hybrid lines of laboratory mice (n=1,661) by means of stereomicroscopy and scanning electron microscopy. In addition, we have reviewed and calculated the incidence and type of BAVs in the published papers dealing with this anomaly in mice. Our results indicate that the Syrian hamster develops BAVs type A and B including a variety of morphologies comparable to those of humans, whereas the mouse develops only BAVs type B with a short spectrum of valve morphologies. Thus, inter-specific differences between human and mouse aortic valves must be taken into consideration when studying valve disease in murine models. This work was supported by P10-CTS-6068.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. P10-CTS-6068.es_ES
dc.language.isoenges_ES
dc.publisherSAGE Publications Press Ldtes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCorazón - Enfermedadeses_ES
dc.subjectAnimales de laboratorioes_ES
dc.titleIncidence and type of bicuspid aortic valve in two model specieses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleI Iberian Congress for Laboratory Animal Science (XIII Congreso SECAL – III Congresso SPCAL)es_ES
dc.relation.eventplaceCáceres, Españaes_ES
dc.relation.eventdate18.11.2015es_ES
dc.identifier.orcidhttps://orcid.org/0000-0002-3293-9384es_ES
dc.cclicenseby-nc-ndes_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem