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dc.contributor.authorVereda-Alonso, Elisa Isabel 
dc.contributor.authorLópez-Guerrero, María del Mar 
dc.contributor.authorSiles-Cordero, Maria Teresa 
dc.contributor.authorCano-Pavón, José Manuel 
dc.contributor.authorGarcía-de-Torres, Amparo 
dc.date.accessioned2015-12-21T11:56:20Z
dc.date.available2015-12-21T11:56:20Z
dc.date.created2015
dc.date.issued2015-12-21
dc.identifier.urihttp://hdl.handle.net/10630/10856
dc.description.abstractNanometer-sized materials have attracted substantial interest in the scientific community because they offer a highly active surface area to volume ratio enable them to have a wide range of potential applications because their great extraction capacity and efficiency. Magnetic nanoparticles (MNPs), as a new kind of nanometer-sized materials, are superparamagnetic, which means that they are attracted to a magnetic field, but retain no residual magnetism after the field is removed. Therefore, suspended superparamagnetic particles adhered to the target can be removed very quickly from a matrix using a magnetic field. In recent years, MNPs have been studied because of their potential applications as magnetic carries for various biomedical uses such as cell and DNA separation, drug delivery system, magnetic resonance imaging, bio separation, and preconcentration of various anions and cations. The excellent properties of MNPs are strongly influenced by the particle size. Transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD) are the main techniques used for the characterization and observation of the size and shape of the MNPs. The objective of this study was to develop a method for direct determination of Fe concentration and particle size of solid MNPs by application of solid sampling high resolution continuum source graphite furnace atomic absorption spectrometry (HR-CS-GFAAS). A new strategy in evaluating the area and the slope of the obtained absorbance signals for a line of Fe with low sensitivity was developed for the determination of both, iron concentration in solid MNPs and their average particle size. For this purpose, five furnace program parameters, atomization temperature, heating rate, and pyrolysis temperature, heating rate and hold pyrolysis time, were optimized with the employ of two multiple response surface designs. The response parameters chosen were: atomization signal area/weighted mass of MNPs and the inverse of the slope of the atomization signal/weighted mass of MNPs. The optimized parameters are shown in Table 1. Table 1. Optimized graphite furnace program Step Temperature (ºC) Heating time (ºC s-1) Hold time (s) Drying 150 5 35 Pyrolysis 1050 75 5 Auto-zero 1050 0 5 Atomization 2500 1275 12 Cleaning 2600 500 4 With these optimized parameters good calibration curves were obtained with liquid iron standards (for Fe determination) and with MNPs samples with certified size particle (for size particle determination). The determination of the MNP size was validated by SEM. This method is being employed in the optimization of the synthesis of MNPs by the coprecipitation method. Key Words: HR-CS-GFAAS, MNPs, Fe concentration, particle size Acknowledgements: The authors thank the Spanish Ministerio de Ciencia y Tecnología (MCyT project no. CTQ2013-44791-P) for supporting this study and also FEDER funds.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Teches_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNaopartículases_ES
dc.subject.otherHR-CS-GFAASes_ES
dc.subject.otherMagnetic nanoparticleses_ES
dc.subject.otherFe concentrationes_ES
dc.subject.otherParticle sizees_ES
dc.titleCharacterization of solid magnetic nanoparticles by high resolution continuum source electrothermal atomic absorption spectrometry (HR-CS-ETAAS)es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle1st International Caparica Christmas Conference on Translational Chemistryes_ES
dc.relation.eventplaceCaparica — Almada, Portugales_ES
dc.relation.eventdate07 Diciembre 2015es_ES
dc.identifier.orcidhttp://orcid.org/orcid.org/0000-0001-9502-4424es_ES
dc.cclicenseby-nc-ndes_ES


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