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dc.contributor.authorIvanov, Plamen Ch.
dc.date.accessioned2016-04-04T09:06:22Z
dc.date.available2016-04-04T09:06:22Z
dc.date.created2016
dc.date.issued2016-04-04
dc.identifier.urihttp://hdl.handle.net/10630/11113
dc.description.abstractThe human organism is an integrated network where multi-component organ systems, each with its own regulatory mechanisms, continuously interact to optimize and coordinate their function. Organ-to-organ interactions occur at multiple levels and spatiotemporal time scales to produce distinct physiologic states: wake and sleep; light and deep sleep; consciousness and unconsciousness. Disrupting organ communications can lead to dysfunction of individual systems or to collapse of the entire organism. Yet, we know almost nothing about the nature of the interactions between diverse organ systems and their collective role in maintaining health. We propose a framework to probe dynamical interactions among physiological systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and physiologic function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach facilitates the development of a new field, Network Physiologyes_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectFisiologíaes_ES
dc.subjectFísica aplicadaes_ES
dc.subject.otherNetwork physiologyes_ES
dc.titleNetwork Physiology: Mapping interactions between complex physiological systemses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleConferencia Departamento Física Aplicada IIes_ES
dc.relation.eventplaceMálagaes_ES
dc.relation.eventdate4 abril 2016es_ES
dc.rights.ccby-nc-nd


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