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dc.contributor.authorVida-Pol, Yolanda 
dc.contributor.authorMolina, Noemi
dc.contributor.authorCollado, Daniel 
dc.contributor.authorNajera, Francisco
dc.contributor.authorLagunas, Anna
dc.contributor.authorClaros, Silvia
dc.contributor.authorBecerra, José
dc.contributor.authorAndrades-Gomez, Jose Antonio 
dc.contributor.authorPerez-Inestrosa, Ezequiel
dc.date.accessioned2016-04-07T11:19:03Z
dc.date.available2016-04-07T11:19:03Z
dc.date.created2016
dc.date.issued2016-04-07
dc.identifier.urihttp://hdl.handle.net/10630/11126
dc.description.abstractMesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface material are critical. Arginine-glycine-aspartic acid tripeptides (RGD) were conjugated to Polyamidoamine (PAMAM) dendrimers and used to pre-treat test surfaces. We demonstrate that dendrimer-presented tripeptides efficiently increase surface cell adhesion to MSCs, and that their effectiveness is related to how they are presented by the dendrimer to the cell. Cell adhesion process is governed by the nanoscale arrangement of the extracellular matrix (ECM), being more affected from local than from global concentration of cell adhesive ligands. Dendrimers grafted on surfaces showed the benefits of the local increase in concentration provided by the dendritic configuration, in many cell-based studies. Dendrimer nanopatterning is applied to address RGD density effects on cell adhesion, where cell experiments showed a clear correlation with dendrimer surface layout. Therefore, dendrimer nanopatterning is presented as a suitable and controlled approach to address the effect of local ligand density in cell response.[es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectRegeneración (Biología)es_ES
dc.subject.otherRGDes_ES
dc.subject.otherDendrimerses_ES
dc.titleRGD peptide on Dendrimer surfaces Affects Mesenchymal Stem Cells Adhesiones_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleIII Biennial Meeting of the Chemical Biology Groupes_ES
dc.relation.eventplaceMadrid, Españaes_ES
dc.relation.eventdate15/03/2016es_ES
dc.identifier.orcidttp://orcid.org/0000-0002-7004-4629es_ES
dc.cclicenseby-nc-ndes_ES


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