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dc.contributor.authorMoreno-Fernández, Román D.
dc.contributor.authorGomez-Salas, Francisco J.
dc.contributor.authorPérez-Martín, Margarita 
dc.contributor.authorRosell-Valle, Cristina
dc.contributor.authorCastilla-Ortega, Estela
dc.contributor.authorGArcía-Fernandez, María I
dc.contributor.authorChun, Jerold
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorEstivill-Torrús, Guillermo
dc.contributor.authorSantín-Nuñez, Luis J.
dc.contributor.authorPedraza-Benítez, Maria del Carmen 
dc.date.accessioned2016-07-20T09:17:05Z
dc.date.available2016-07-20T09:17:05Z
dc.date.created2016
dc.date.issued2016-07-20
dc.identifier.urihttp://hdl.handle.net/10630/11856
dc.description.abstractStress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders such as depression. The neurobiological circuitry in charge of dealing with stressors has been widely studied in animal models. Recently our group has demonstrated a role for lysophosphatidic acid (LPA) through the LPA1 receptor in vulnerability to stress, in particular the lack of this receptor relates to robust decrease of adult hippocampal neurogenesis and induction of anxious and depressive states. Nevertheless, the specific abnormalities in the limbic circuit in reaction to stress remains unclear. The aim of this study is to examine the differences in the brain activation pattern in the presence or absence of LPA1 receptor after acute stress. For this purpose, we have studied the response of maLPA1-null male mice and normal wild type mice to an intense stressor: Tail Suspension Test. Activation induced by behaviour of brain regions involved in mood regulation was analysed by stereological quantification of c-Fos immunoreactive positive cells. We also conducted multidimensional scaling analysis in order to unravel coativation between structures. Our results revealed hyperactivity of stress-related structures such as amygdala and paraventricular nucleus of the hypothalamus in the knockout model and different patterns of coactivation in both genotypes using a multidimensional map. This data provides further evidence to the engagement of the LPA1 receptors in stress regulation and sheds light on different neural pathways under normal and vulnerability conditions that can lead to mood disorders.es_ES
dc.description.sponsorshipUniversidad de Malaga, Campus de Excelencia internacional Andalucía Tech. Andalusian Ministry of Economy, Innovation, Science and Employment (SEJ1863); Postdoctoral Fellowship ‘Sara Borrell’ of the National Institute of Health Carlos III E. C.; Grant of the Andalusian Ministry of Economy, Innovation , Science and Employment C. R. (FPDI 2010). Grant of the Spanish Ministry of Education, Culture and Sport s (FPU14/01610).es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectReceptores de neurotransmisoreses_ES
dc.subject.otherDepressiones_ES
dc.subject.otherLimbic Systemes_ES
dc.subject.otherLPA1 receptores_ES
dc.titleAbsence of LPA1 receptor results in altered pattern of limbic activation after tail suspension testes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicologíaes_ES
dc.relation.eventtitle10th FENS Forumes_ES
dc.relation.eventplaceCopenhague, Dinamarcaes_ES
dc.relation.eventdateJulio 2016es_ES
dc.cclicenseby-nc-ndes_ES


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