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dc.contributor.authorMillón, Carmelo
dc.contributor.authorFlores-Burgess, Antonio
dc.contributor.authorNarváez, Manuel 
dc.contributor.authorBorroto-Escuela, Dasiel
dc.contributor.authorSantín, Luís
dc.contributor.authorGago, Belén
dc.contributor.authorParrado, Concepción
dc.contributor.authorGomez de Travecedo, Isabel
dc.contributor.authorNarváez, José Ángel 
dc.contributor.authorFuxe, Kjell
dc.contributor.authorDíaz-Cabiale, Zaida 
dc.date.accessioned2016-07-27T08:29:48Z
dc.date.available2016-07-27T08:29:48Z
dc.date.created2016
dc.date.issued2016-07-27
dc.identifier.urihttp://hdl.handle.net/10630/11896
dc.description.abstractGalanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In this study, we have analysed the ability of GAL(1-15) to modulate the effects of the 8-OH-DPAT agonist in the Forced Swimming Test (FST). Groups of rats were assessed in the FST. In the first set of experiments, to evaluate the interactions of 8-OH-DPAT and GAL(1-15), rats received subcutaneously (s.c) the effective doses of 8-OH-DPAT (0.25mg/Kg) 60min before the test and intracerebroventricularly (icv) GAL(1-15)1nmol 15min before the tests alone or in combination. In the second set of experiments, groups of rats received s.c. 8-OH-DPAT (0.125mg/Kg), icv GAL(1-15) 1nmol and icv the GALR2 antagonist M871 3 nmol alone or in combination. The locomotor activity was analysed in the open field test. GAL(1-15) 1nmol enhanced the antidepressant-like effects mediated by the effective dose of the 8-OH-DPAT. GAL(1-15) significantly decreased the immobility (p<0.05) and climbing (p<0.05) and increased the swimming (p<0.01) behaviour induced by an effective dose of 8-OH-DPAT (0.25mg/Kg) in FST. Moreover, after coadministration of GAL(1-15) and threshold dose of 8-OH-DPAT (0.125mg/Kg) a significant decreased appeared in immobility (p<0.01) and climbing (p<0.01) and increased the swimming behavior (p<0.001) vs 8-OH-DPAT group. Moreover, M871 blocked completely this interaction. These results indicate that GAL(1-15) enhances the antidepressant effects induced by 8-OH-DPAT in the FST. These findings may give the basis for the development of novel therapeutic drugs. This study was supported by Junta de Andalucía CVI6476.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This study was supported by Junta de Andalucía CVI6476.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDepresión mentales_ES
dc.subject.otherGalanines_ES
dc.subject.other5HT1Aes_ES
dc.subject.otherGAL(1-15)es_ES
dc.subject.otherDepressiones_ES
dc.titleGalanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleFENS 2016es_ES
dc.relation.eventplaceCopenhaguees_ES
dc.relation.eventdate2 July 2016es_ES
dc.cclicenseby-nc-ndes_ES


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