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dc.contributor.authorFlores-Burgess, Antonio 
dc.contributor.authorMillón-Peñuela, Carmelo 
dc.contributor.authorNarváez-Peláez, Manuel 
dc.contributor.authorBarroto-Escuela, Dasiel
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.contributor.authorGago-Calderón, Belén 
dc.contributor.authorGomez de Travecedo, Isabel
dc.contributor.authorNarváez-Bueno, José Ángel 
dc.contributor.authorFuxe, Kjell
dc.contributor.authorDíaz-Cabiale, Zaida 
dc.date.accessioned2016-09-09T07:47:27Z
dc.date.available2016-09-09T07:47:27Z
dc.date.created2016
dc.date.issued2016-09-09
dc.identifier.urihttp://hdl.handle.net/10630/11970
dc.descriptionPoster en Congresoes_ES
dc.description.abstractWe have described that Galanin N-terminal fragment (1-15) [GAL(1-15)] is associated with depressive effects and also modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist 8-OH-DPAT. The aim of this study is to analyze the ability of GAL(1-15) to modulate 5-HT1AR at the autoreceptor and postsynaptic receptor level in rats by using quantitative autoradiography. We analyzed the effect of intracerebroventricular GAL(1-15)-3nmol (n=6) or aCSF (n=6), 10 minutes, 2 and 5 hours after the injection, on the binding characteristics of the 5-HT1AR agonist [H3]-8-OH-DPAT in sections of the Dorsal Raphe (DR) and Dorsal Hippocampus, specifically CA1 and Dentate Gyrus (DG). Student’s t-test was used to compare the experimental groups. GAL(1-15) produced a time-dependent effect on the binding of [H3]-8-OH-DPAT. In CA1 and DG, a significant increase in the KD and Bmax was observed, by 90%(p<0.05), at 10 minutes and 2 hours after injection. However, 5 hours after GAL(1-15) the only significant change remaining was the increase in Bmax at the DG. The coinjection of the GALR2 antagonist M871 blocked significantly the effects induced by GAL(1-15) in both areas. In DR, 2 hours after injection GAL(1-15) only produced a decrease in the Bmax by 20%(p<0.05). These results indicate that GAL(1-15) interacts with 5-HT1AR at the receptor level in DR and Dorsal Hippocampus. Therapeutic strategies based on these results could be developed for the treatment of depression disorders. This work has been supported by Junta de Andalucia CVI646 and Spanish Ministry of Economy PSI2013-44901-P.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHipocampo (Cerebro)es_ES
dc.subjectNeuropéptidoses_ES
dc.subject.otherGalanines_ES
dc.subject.otherRaphees_ES
dc.subject.otherHippocampuses_ES
dc.subject.otherAutoradiographyes_ES
dc.titleGalanin n-terminal gragment (1-15) modifies the 5-HT1A receptor against [H3]-8-OH-DPAT binding in the dorsal raphe and hippocampus of the rates_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleFENSes_ES
dc.relation.eventplaceCopenhaguees_ES
dc.relation.eventdateJulio 2016es_ES
dc.cclicenseby-nc-ndes_ES


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