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New bodipy dyads for two-photons fluorescence imaging in cells
dc.contributor.author | Collado-Martín, Daniel | |
dc.date.accessioned | 2016-09-13T11:21:29Z | |
dc.date.available | 2016-09-13T11:21:29Z | |
dc.date.created | 2016 | |
dc.date.issued | 2016-09-13 | |
dc.identifier.uri | http://hdl.handle.net/10630/11995 | |
dc.description.abstract | Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed particular interest in the development of two-photon excitable probes, due to their advantageous features in tissue imaging compared to the corresponding one-photon probes [1]. Recently, we have designed and synthetized an aminonaphthalimide–BODIPY derivative as energy transfer cassettes and were found to show very fast and efficient BODIPY fluorescence sensitization [2]. This was observed upon one- and two-photon excitation, which extends the application range of the investigated bichromophoric dyads in terms of accessible excitation wavelengths. In order to increase the two-photon absorption of the system aminonaphthalimide fluorophore was replace with a Prodan analog (BODIPY dyad 1), which presents found a variety of applications as probes and labels in biology [3]. The two-photon absorption cross-section of the dyads is significantly incremented by the presence of the 6-acetyl-2-naphthylamine donor group. The emission maximum of a BODIPY fluorophore can significantly be red-shifted in comparison to their precursors by conjugation with aromatic aldehydes. [4] We use a synthetic strategy to obtain BODIPY dyad 2 that incorporates an imidazole ring. This molecule can be used in biological media as a near-neutral pH indicator based on one- and two-photon excitable BODIPY acceptor. | es_ES |
dc.description.sponsorship | Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Fotoquímica | es_ES |
dc.subject | Fotobioquímica | es_ES |
dc.subject.other | Photochemistry | es_ES |
dc.subject.other | Energy transfer | es_ES |
dc.title | New bodipy dyads for two-photons fluorescence imaging in cells | es_ES |
dc.type | info:eu-repo/semantics/conferenceObject | es_ES |
dc.centro | Facultad de Ciencias | es_ES |
dc.relation.eventtitle | Vth Spanish-Portuguese Workshop on Photochemistry | es_ES |
dc.relation.eventplace | Toledo | es_ES |
dc.relation.eventdate | 07/09/2016 | es_ES |
dc.identifier.orcid | http://orcid.org/0000-0002-8155-7112 | es_ES |
dc.cclicense | by-nc-nd | es_ES |