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dc.contributor.authorPerez-Inestrosa, Ezequiel
dc.contributor.authorVida-Pol, Yolanda 
dc.contributor.authorCollado, Daniel 
dc.contributor.authorNajera-Albendin, Francisco 
dc.contributor.authorMesa-Antunez, Pablo
dc.contributor.authorRuiz-Sanchez, Antonio
dc.contributor.authorMolina, Noemi
dc.contributor.authorMorgado, Anjara
dc.date.accessioned2017-06-30T11:36:42Z
dc.date.available2017-06-30T11:36:42Z
dc.date.created2017
dc.date.issued2017-06-30
dc.identifier.urihttp://hdl.handle.net/10630/14083
dc.description.abstractDendrimers that are modified through their peripheral groups have been employed for many biomedical purposes. Diagnosis via specific interactions with target proteins is one of the objectives that has been given more attention. In this way, we have been developing different methodologies for the detection of immunoglobulins, as an in vitro method for the diagnosis of allergic reactions to drugs [1], [2]. Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density effects on cell adhesion, as bioactive substrates to evaluate the impact of the RGD local surface density on the chondrogenic induction of adult human mesenchymal stem cells [3], [4], [5]. Although the use of PAMAM dendrimer has allowed us to develop useful methods for this purpose, for certain objectives we have required the development of new dendrimeric models. We have developed a new approach for the production of allaliphatic polyamide dendrimers (BAPAD) by iterative 3,3′-diaminopivalic acid connections as building blocks for dendrimer construction. These dendrimers were studied in explicit solvent by atomistic forcefield-based molecular dynamics to characterize structural properties such as shape, radius and monomer distribution [6]. Fluorescent labeling of these biomimetic dendrimers has been used as a tool to study their interaction with cells.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDendrímeroses_ES
dc.subjectCompuestos organofluoradoses_ES
dc.subject.otherDendrimerses_ES
dc.subject.otherDrug Allergyes_ES
dc.subject.otherRGDes_ES
dc.subject.otherMSCes_ES
dc.subject.otherOne-Two Photon Fluorescencees_ES
dc.titleManaging with (fluorescent)-biomimetic dendrimerses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleXXXVI Reunión Bienal de la Real Sociedad Española de Química (RSEQ)es_ES
dc.relation.eventplaceSitges, Barcelonaes_ES
dc.relation.eventdate25 junio/2017es_ES
dc.cclicenseby-nc-ndes_ES


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