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dc.contributor.authorAguera-Suárez, Ana María
dc.contributor.authorPorras Alcalá, Cristina
dc.contributor.authorGuerreo Vásquez, Guillermo A.
dc.contributor.authorCheng-Sánchez, Iván
dc.contributor.authorSarabia, Francisco
dc.date.accessioned2017-07-20T09:51:57Z
dc.date.available2017-07-20T09:51:57Z
dc.date.created2017
dc.date.issued2017-07-20
dc.identifier.urihttp://hdl.handle.net/10630/14281
dc.description.abstractIsolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. The recognition of these natural products as antiangiogenic compounds, in virtue to their inhibition of methionine aminopeptidases, prompted intense research activities in the chemical and biological fields. In fact, the total synthesis of the natural products, together with an extensive variety of analogues, has been reported in the literature [2]. Particularly, we have recently developed a new synthetic methodology which allowed rapid and efficient access to the natural bengamide E (1), together with a wide library of analogues of which the cyclopentyl analogue 2 was identified as a more potent antitumor compound with respect to its natural congener [3]. As continuation of these synthetic efforts, with the objective of identifying new potent and promising analogues, we wish to report our recent synthetic studies directed to the synthesis of new bengamide analogues, featured by the replacement of the caprolactam fragment by a peptidyl residue (compounds type 3). On the other hand, in order to gain insight into the mechanism of the biological action of the bengamides, we describe the preparation of the N-alkyl derivatives 4 and 5, which represent interesting molecules that could be employed as suitable molecular probes.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAntineoplásicoses_ES
dc.subject.otherNatural productses_ES
dc.subject.otherAnalogueses_ES
dc.subject.otherBengamideses_ES
dc.subject.otherAntitumor Agentses_ES
dc.titleSynthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probeses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle20th European Symposium on Organic Chemistry (ESOC’17)es_ES
dc.relation.eventplaceColonia, Alemaniaes_ES
dc.relation.eventdateJulio, 2017es_ES
dc.identifier.orcidhttp://orcid.org/X0000-0002-5149-3576es_ES
dc.cclicenseby-nc-ndes_ES


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