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dc.contributor.authorLucena-Serrano, Cristina
dc.contributor.authorLucena-Serrano, Ana
dc.contributor.authorLópez-Romero, Juan Manuel 
dc.contributor.authorDíaz, Amelia
dc.contributor.authorValpuesta-Fernandez, Maria 
dc.date.accessioned2017-07-20T10:18:54Z
dc.date.available2017-07-20T10:18:54Z
dc.date.created1917
dc.date.issued2017-07-20
dc.identifier.urihttp://hdl.handle.net/10630/14283
dc.description.abstractThe 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of 1-aryl tetrahydroisoquinoline are used for the treatment of neurodegenerative diseases such as Parkinson´s and Alzheimer´s diseases since also act as dopaminergic antagonists and N-methyl-D-aspartate receptor antagonist. [1] The 1-substituted tetrahydro-3-benzazepines have also been studied for their affinity to the Phencylclidine binding site of the NMDA receptor as well as for their affinity to the dopaminergic receptors. [2] In the last years, various methods have been carried out to satisfy the demand of novel tetrahydroisoquinolines and tetrahydro-3-benzazepines. We have synthesized nor-1-aryl tetrahydroisoquinolines with different substituents in the aryl group of C-1 (H, NMe2, SMe, NO2, NH2). In addition to this, we have performed the synthesis of nor-tetrahydro-3-benzazepinas by different routes, obtaining the best results via opening of epoxides by arylphenethylamines and subsequent cyclization. The nor-tetrahydroisoquinolines and nor-tetrahydro-3-benzazepines have been derivatized to obtain appropiate adsorbates which can be attached to nanoparticles. This fact is crutial in drug delivery systems as well as in the improvement of the biocompatibility of these compounds. Literature: [1] Toshiaki Saitoh, Eur. J. Med. Chem. 2006, 41, 241. Mattias Ludwig, Eur. J. Med. 2006, 41, 1003. [2] Olaf Krull, Bioorg. Med. Chem. 2004, 12, 1439.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Teches_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCompuestos bioactivoses_ES
dc.subjectNanopartículases_ES
dc.subject.other1-aryl tetrahydroisoquinolineses_ES
dc.subject.otherBioactive Compoundses_ES
dc.subject.otherNanoparticleses_ES
dc.subject.otherTetrahydro-3-benzazepineses_ES
dc.titleSynthesis of bioactive compounds. Studies of their attachment to nanoparticleses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle20th European Symposium on Organic Chemistry, ESOCes_ES
dc.relation.eventplaceColonia, Alemaniaes_ES
dc.relation.eventdate2-6 julio 2017es_ES
dc.identifier.orcidhttp://orcid.org/0000-0002-9956-5583es_ES
dc.cclicenseby-nc-ndes_ES


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