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dc.contributor.authorMoreno-Fernández, Román D.
dc.contributor.authorTabbai, S.
dc.contributor.authorGómez-Salas, Francisco J.
dc.contributor.authorPérez-Martín, Margarita 
dc.contributor.authorRosell-Valle, Cristina
dc.contributor.authorCastilla-Ortega, Estela
dc.contributor.authorGarcía-Fernandez, María
dc.contributor.authorChun, Jerold
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorEstivill-Torrús, Guillermo
dc.contributor.authorSantín-Nuñez, Luis J.
dc.contributor.authorPedraza-Benítez, Maria del Carmen 
dc.date.accessioned2017-09-01T10:49:30Z
dc.date.available2017-09-01T10:49:30Z
dc.date.issued2017-07
dc.identifier.urihttp://hdl.handle.net/10630/14420
dc.description.abstractAdverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing with stressors has been widely studied in animal models. Our group has demonstrated a role for lysophosphatidic acid (LPA) through the LPA1-receptor in controlling anxious and depressive states, owing to aggravation of the detrimental consequences of stress in the brain. Indeed, our group has recently proposed the variant maLPA1-null mice, i.e. mice lacking the LPA1 receptor, as an endophenotype for anxious depression. In addition, we have previously reported hyperactivation of key stress-related brain areas after stress, such as basolateral amygdala. Here, we seek to further examine the engagement of the LPA1 receptor in the regulation of the limbic circuit following an acute stressor, tail suspension test, in wildtype and knockout animals. To that end, c-Fos expression was evaluated as a measure of functional activity in both basal and stress conditions, followed by interregional correlation matrices to establish the brain map of functional activation. Additionally, we observed whether one single dose of the antidepressant treatment with desipramine is able to normalize the functional brain map. Results revealed that the absence of the LPA1 receptor induce an anomalous pattern of brain functional activity after TST, which was reverted by desipramine administration.These results provide further insight to the involvement of the LPA1 receptor in stress regulation and shed light on divergent brain pathways under normal and vulnerability conditions that can be implicated in depressive symptoms. Finally, how this pattern might be reverted by antidepressant treatment can be useful for developing new pharmaceutical targets regarding the LPA1 receptor.es_ES
dc.description.sponsorshipFunding: Andalusian Ministry of Economy, Innovation, Science and Employment (SEJ1863 to C.P) and of Health (Nicolas Monardes programme, to G.E-T); the Spanish Ministry of Economy and Competitiveness (PSI2013-44901-P to L.J.S. and C.P.). Author R.D. M-F holds a Grant of the Spanish Ministry of Education, Culture and Sports (FPU14/01610). Author S.T. holds a Grant of the Andalusian Ministry of Economy, Innovation, Science and Employment (FPDI 2014). I Plan Propio de Investigación y Transferencia, Universidad de Málaga. Campus de Excelencia. Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.publisherUNEDes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectReceptores de neurotransmisoreses_ES
dc.subject.otherLPA1 receptores_ES
dc.subject.otherLimbic Systemes_ES
dc.subject.otherDepressiones_ES
dc.titleThe limbic brain under stress: a role for the LPA1 receptores_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicologíaes_ES
dc.relation.eventtitle2nd International Congress of Psycobiologyes_ES
dc.relation.eventplaceÁvilaes_ES
dc.relation.eventdatejulio 2017es_ES
dc.cclicenseby-nc-ndes_ES


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