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dc.contributor.authorContreras Cáceres, Rafael
dc.date.accessioned2017-09-21T10:29:17Z
dc.date.available2017-09-21T10:29:17Z
dc.date.created2017
dc.date.issued2017-09-21
dc.identifier.urihttp://hdl.handle.net/10630/14515
dc.description.abstractWe present the synthesis a of pH-responsive core@shell hybrid microgel. This colloidal system is formed by a 55 nm Au core individually covered by a polymeric pH-sensitive shell of poly(4-vinylpyridine), that we denote as Au@p4VP. Initially, we control the microgel thickness from 51 to 10 nm, and we confirm the pH- responsive capability of Au@p4VP by DLS measurements, showing a swelling degree, which depends on the pH of the media and the crosslinker density within the polymer network. We also prove the hybrid structure by plotting the UV-vis spectra at different pH values, showing a surface plasmon band displacement in function of pH. Thus, at acidic pH the microgel swells due to the electrostatic repulsion created into the polymer matrix, while at high pH, the microgel structure collapses because of the reduction in the electrostatic repulsion and the increment of the hydrophobic interactions. This capability is exploited to introduce doxorubicin molecules into the microgel network which are detected by surface- enhanced Raman spectroscopy (SERS). After increasing the pH of the solution, the captured molecules are brought in close proximity to the surface of the metallic core, enhancing its detection by SERS.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectPolímeroses_ES
dc.subject.otherNanoparticleses_ES
dc.subject.otherGoldes_ES
dc.subject.otherSerses_ES
dc.subject.otherMicrogelses_ES
dc.titleHybrid pH-Responsive Au@p4VP Microgels as Platform for Selective SERS Analysises_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.relation.eventtitleECISes_ES
dc.relation.eventplaceMadrid, Españaes_ES
dc.relation.eventdate5 septiembre 2017es_ES
dc.cclicenseby-nc-ndes_ES


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