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dc.contributor.authorGarcía-Vilas, Javier A.
dc.contributor.authorQuesada, Ana R.
dc.contributor.authorMedina, Miguel Ángel 
dc.date.accessioned2017-10-13T09:52:32Z
dc.date.available2017-10-13T09:52:32Z
dc.date.created2016-10-24
dc.date.issued2017-04
dc.identifier.urihttp://hdl.handle.net/10630/14632
dc.descriptionThis is the preprint version of our manuscript, corresponding to the article that has been 
published in final form at FOOD CHEMISTRY with DOI: 10.1016/j.foodchem.2016.10.111es_ES
dc.description.abstractThe health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further insight into the effects of hydroxytyrosol on extracellular matrix remodeling; and ii) test whether hydroxytyrosol is able to inhibit angiogenesis ex vivo and in vivo. Hydroxytyrosol induced a shift toward inhibition of proteolysis in endothelial cells, with decreased expression of extracellular matrix remodeling-enzyme coding genes and increased levels of some of their inhibitors. Furthermore, this work demonstrated that hydroxytyrosol, at concentrations within the range of its content in virgin olive oil that can be absorbed from moderate and sustained virgin olive oil consumption, is a strong inhibitor of angiogenesis ex vivo and in vivo. These results suggest the need for translational studies to evaluate the potential use of hydroxytyrosol for angio-prevention and angiogenesis inhibition in clinical setting.es_ES
dc.description.sponsorshipThis work was supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER). The “CIBER de Enfermedades Raras” is an initiative from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAceite de olivaes_ES
dc.subject.otherAngiogenesises_ES
dc.subject.otherAortic ring assayes_ES
dc.subject.otherVine aorta endothelial cells (BAEC)es_ES
dc.subject.otherChorioallantoic membrane (CAM) assayes_ES
dc.subject.otherHydroxytyrosoles_ES
dc.subject.otherMatrix metalloproteinesa (MMP)es_ES
dc.subject.otherTissue inhibitor of metalloproteinese (TIMP)es_ES
dc.subject.otherUrokinase-type plasminogen activator (UPA)es_ES
dc.titleHydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesises_ES
dc.typeinfo:eu-repo/semantics/preprintes_ES
dc.centroFacultad de Cienciases_ES
dc.cclicenseby-nc-ndes_ES


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