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dc.contributor.authorOcaña, Mª Carmen
dc.contributor.authorCarrillo, Paloma
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorQuesada, Ana R.
dc.contributor.authorMedina, Miguel Ángel 
dc.date.accessioned2017-10-31T10:42:41Z
dc.date.available2017-10-31T10:42:41Z
dc.date.created2017
dc.date.issued2017-10-31
dc.identifier.urihttp://hdl.handle.net/10630/14739
dc.descriptionEs comunicación a congreso en formato pósteres_ES
dc.description.abstractThe role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic effects. Fasentin is a poor-studied inhibitor of glucose uptake which modulates GLUT-1 and GLUT-4 transporters in cancer cells. We wanted to test its possible effect on EC glucose uptake, showing a light decrease in HMEC at 100 µM. Lower doses did not affect this characteristic of glucose metabolism. In line with this fact, fasentin at 100 µM totally inhibited tube formation on Matrigel in these cells. This anti-angiogenic effect is not likely to be helped by a pro-apoptotic effect of fasentin but, as proved with additional assays, it could be due to a decrease on the signaling for extracellular matrix degradation. More research would be necessary in order to elucidate its fine regulation on angiogenesis and metabolism.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"].es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAntiangiogénicoses_ES
dc.subject.otherAngiogenesises_ES
dc.subject.otherGlucose uptakees_ES
dc.subject.otherFasentines_ES
dc.titleFasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesises_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleFEBS3+-XL SEBBM Congresses_ES
dc.relation.eventplaceBarcelonaes_ES
dc.relation.eventdate23 de octubre de 2017es_ES
dc.identifier.orcidhttp://orcid.org/0000-0001-7275-6462es_ES
dc.cclicenseby-nc-ndes_ES


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