Mostrar el registro sencillo del ítem

dc.contributor.authorCarrilo, Paloma
dc.contributor.authorCheng-Sánchez, Iván
dc.contributor.authorOcaña, Mª Carmen
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorMedina, Miguel Ángel 
dc.contributor.authorSarabia, Francisco
dc.contributor.authorQuesada, Ana R.
dc.date.accessioned2017-11-09T07:19:59Z
dc.date.available2017-11-09T07:19:59Z
dc.date.created2017
dc.date.issued2017-11-09
dc.identifier.urihttp://hdl.handle.net/10630/14768
dc.descriptionEs comunicación (formato panel) a congreso internacionales_ES
dc.description.abstractIn this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ring contained in these natural products. During the synthetic process, a diverse set of analogues was generated and we evaluated their potential antitumor activity in vitro. For this purpose we performed in vitro proliferation assays, determining the IC50 values of the compounds in a panel of tumor cell lines. In addition, we evaluated the possible antiangiogenic effects of these solomonamide analogues by using in vitro endothelial cell differentiation assays. Our results showed that the potential antitumor and antiangiogenic activity of the studied analogues depended on their chemical structure, suggesting that the presence of specific functional groups could be responsible of their biological activity. Further studies are needed to understand the basis of the observed activities in endothelial and tumor cells.es_ES
dc.description.sponsorshipOur experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAngiogénesises_ES
dc.subject.otherMarine natural compoundses_ES
dc.subject.otherSolomonamidees_ES
dc.titleAntitumor and antiangiogenic potential of solomonamide synthesis intermediateses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleFEBS3+-XL SEBBM Congresses_ES
dc.relation.eventplaceBarcelonaes_ES
dc.relation.eventdate23 de octubre de 2017es_ES
dc.cclicenseby-nc-ndes_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem