Mostrar el registro sencillo del ítem

dc.contributor.authorKim, Sanghee
dc.date.accessioned2018-03-22T11:22:05Z
dc.date.available2018-03-22T11:22:05Z
dc.date.created2018
dc.date.issued2018-03-22
dc.identifier.urihttps://hdl.handle.net/10630/15469
dc.description.abstractThe chirality of a starting material having a chiral sp3-carbon can be preserved under some circumstances in the reaction product even though the reaction proceeds at the chiral carbon as a reaction center through reactive intermediates. This process is defined as Memory of chirality (MOC). MOC is an attractive strategy for asymmetric synthesis, but it has found limited applications. There are only few reports of MOC being applied in the total synthesis of natural products. In recent years, we have been involved in the total synthesis of biological interesting alkaloid natural products and their analogues without the aid of external chiral influences. Representative alkaloids of such interest include penibruguieramine, drupacine, lepadiformines, salinosporamides, and oxazolomycins. The principle of MOC is applied for the asymmetric synthesis of these alkaloids using an appropriate amino acid as the only chiral source. In this presentation, I would like to share our old and new progress on this subject. A mechanistic rationale would be discussed for the excellent stereochemical outcome of MOC reactions.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSíntesis asimétricaen_US
dc.subject.otherTotal synthesisen_US
dc.subject.otherAsymmetric Synthesisen_US
dc.subject.otherNatural Productsen_US
dc.subject.otherAlkaloiden_US
dc.titleAsymmetric total synthesis of alkaloid natural products without external chiral sourcesen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleConferenciaen_US
dc.relation.eventplaceMálagaen_US
dc.relation.eventdate14-03-2018en_US


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem