Research has shown that difficulties in family functioning contribute to developing adolescents’
depressive symptoms. Additionally, little research has been conducted in order to analyze socio-economic
status (SES) differences in the relationship between family functioning and adolescent depressive
symptoms. This study examined the relationships between the family variables included in the
MacMaster Model of Family Functioning (MMFF), SES and depressive symptoms, as well as the
mediating effects of hopelessness. Participants were 643 adolescents aged 12 to 18 years (49% male)
drawn from secondary schools in Málaga (Spain). They completed the Family Assessment Device, the
Beck Depression Inventory, the Beck Hopelessness Scale, and a socio-economic measure. We used
conditional process analysis to test the moderation effect of gender and a dual mediation model with
family functioning and hopelessness as mediators. Results showed that both family functioning as a
whole and each MMFF variable, as well as SES, predicted adolescents’ depressive symptoms. In
addition, gender moderated the relationship of roles assignment and behavioral control with adolescents’
depressive symptoms, which suggests the need for interventions directed to enhance family rules and
boundaries, especially for boys. Finally, we found a serial mediational role of family functioning and
hopelessness in the relationship between SES and depressive symptoms, suggesting that the effect of
family SES on adolescents’ depressive symptoms through the development of hopelessness should also
be targeted.