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dc.contributor.authorMorales Loyola, Rodrigo
dc.date.accessioned2018-06-01T10:38:11Z
dc.date.available2018-06-01T10:38:11Z
dc.date.created2018
dc.date.issued2018-06-01
dc.identifier.urihttps://hdl.handle.net/10630/15891
dc.description.abstractTransmissible Spongiform Encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders affecting mammals. Albeit their low incidence in humans, prion diseases are a subject of passionate research due to their unorthodox mechanisms of transmission mediated by misfolded proteins, and the zoonotic potential of Bovine Spongiform Encephalopathy (BSE or “mad cow” disease). Importantly, prion diseases in deer and sheep can be prevalent and persistent, raising important concerns in terms of public health due to their uncontrolled spread and possible transmission to humans. Importantly, the accumulation of misfolded protein aggregates is not an exclusive feature of TSEs, but also present in several other pathological conditions including Alzheimer’s Disease (AD), Parkinson´s disease, type-2 diabetes, and others. Recent reports suggest that the spread of misfolded proteins and further pathological features in these diseases operates in a similar manner as seen for infectious prions. This has opened controversial and prolific lines of investigation that are currently being explored by several research groups around the world. In this presentation, I will focus on recent advances for prion detection in Chronic Wasting Disease (CWD), a TSE of cervids. In addition, mechanistic aspects of CWD transmission will be discussed, including horizontal and environmental transmission, role of prion protein polymorphisms in prion strain variation, and others. The second part of my talk will center on our research exploring whether features that define prions as infectious agent exist on AD’s amyloid-β. Specifically, the possibility of inter-individual transmission, presence of conformational strain variation, etc. on misfolded amyloid-β will be discussed. My aim in this talk is to highlight the common mechanisms of spread for prions and amyloid-β, and suggest common strategies for early diagnosis based in the prion-principle.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlzheimer, Enfermedad deen_US
dc.subject.otherPrionesen_US
dc.subject.otherNeurodegeneraciónen_US
dc.subject.otherAmiloideen_US
dc.titleAre amyloids infectious? Prions and prion-like proteins: myths and factsen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleConferencia Científicaen_US
dc.relation.eventplaceMálaga, Españaen_US
dc.relation.eventdate29 Mayo 2018en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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