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dc.contributor.authorNajera-Albendin, Francisco 
dc.contributor.authorBenitez-Martin, Carlos
dc.contributor.authorGuadix, Juan Antonio
dc.contributor.authorPerez-Pomares, Jose Maria 
dc.contributor.authorPerez-de-Inestrosa-Villatoro, Ezequiel 
dc.date.accessioned2018-06-28T07:00:55Z
dc.date.available2018-06-28T07:00:55Z
dc.date.created2018
dc.date.issued2018-06-20
dc.identifier.citationXXVII Biennial Meeting in Organic Chemistryen_US
dc.identifier.urihttps://hdl.handle.net/10630/16041
dc.description.abstractReactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS is a phenomenon that results from normal cell metabolism as well as from the response to certain pathologic stimuli like certain cytokines, xenobiotics and bacterial infection. These ROS are highly reactive, short-lived molecules that play critical roles in the living cell and it is well accepted that cellular oxidative stress results from the imbalance between generation and elimination of ROS in cells. In this work, we describe the design and synthesis of a two photon (TP) organelle-targeting activatable fluorescent probe. This probe is a naphthalene-indoline compound that targets specifically lysosomes, reaching these organelles in the fluorescence “off” state and minimizing background reactions. Upon arrival at the lysosomes, the probe is triggered and a fluorescence “on” signal is observed that can be combined with TP microscopy to image the lysosomal •OH in living cells.en_US
dc.description.sponsorshipReal Sociedad Española de Química y Grupo Especializado de Química Orgánica de la RSEQ•Universidade de Santiago de Compostela • CIQUS • Lilly • Mestrelab Research •Thieme •Scharlab • Acros • ABCR • AMSLab • GalChimia • Elsevier • The Journal of the American Chemical Society • ACS Omega • Organic Letters • The Journal of Organic Chemistry • Accounts of Chemical Research. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Techen_US
dc.language.isoengen_US
dc.publisherReal Sociedad Española de Químicaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectQuímica orgániza - Congresosen_US
dc.subject.otherMEF Cellsen_US
dc.subject.otherFluorescent Probeen_US
dc.subject.otherTwo photon absorptionen_US
dc.subject.otherReactive oxygen speciesen_US
dc.subject.otherHydroxyl radicalen_US
dc.subject.otherFluorescent probeen_US
dc.titleDetecting hydroxyl radical with a new two-photon fluorescent probe in living cellsen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.typeinfo:eu-repo/semantics/otheren_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleXXVII Biennial Meeting in Organic Chemistryen_US
dc.relation.eventplaceSantiago de Compostela (Spain)en_US
dc.relation.eventdatejunio 2018en_US


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