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dc.contributor.authorBenítez-Martín, Carlos
dc.contributor.authorNájera-Albendín, Francisco 
dc.contributor.authorPérez-de-Inestrosa-Villatoro, Ezequiel 
dc.date.accessioned2018-07-06T06:46:20Z
dc.date.available2018-07-06T06:46:20Z
dc.date.created2018
dc.date.issued2018-06-20
dc.identifier.urihttps://hdl.handle.net/10630/16147
dc.description.abstractFluorescence-based biosensors have become essential tools for modern biology, allowing real-time monitoring of biological processes within living cells. The differences between pH play a significant role in multiple biological process such as proliferation, apoptosis, endocytic process and defense. Therefore, intracellular fluorescent pH probes comprise one of the most widely used families of biosensors in microscopy. In this work, we present the design, synthesis and characterization of new one and two photon pH activatable fluorescent probes based on naphthalene-indoline derivatives with an off-on response to different pH environments. These compounds are easy to achieve with good yields and have good photophysical properties. Simple modifications in the structure of these compounds allow tuning their pKa easily and cover a width range of pH in their applications. The preliminary results obtained with these fluorescent probes indicate that they have promising properties to be use in bioimaging applications in living cells.en_US
dc.description.sponsorshipReal Sociedad Española de Química y Grupo Especializado de Química Orgánica de la RSEQ•Universidade de Santiago de Compostela • CIQUS • Lilly • Mestrelab Research •Thieme •Scharlab • Acros • ABCR • AMSLab • GalChimia • Elsevier • The Journal of the American Chemical Society • ACS Omega • Organic Letters • The Journal of Organic Chemistry • Accounts of Chemical Research. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.publisherReal Sociedad Española de Químicaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectQuímica orgánica - Congresosen_US
dc.subject.otherpH sensoren_US
dc.subject.otherIndolineen_US
dc.subject.otherTwo-photon absorptionen_US
dc.titleTuning pKa in new molecules based on indolines for two-photon absorption bioimaging applicationsen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleXXVII Biennial Meeting in Organic Chemistryen_US
dc.relation.eventplaceSantiago de Compostela (España)en_US
dc.relation.eventdatejunio de 2018en_US


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