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dc.contributor.authorGonzález-García, Marta
dc.contributor.authorLópez-González, Manuel Víctor 
dc.contributor.authorDíaz-Casares, Amelia 
dc.contributor.authorPeinado-Aragonés, Carlos Antonio
dc.contributor.authorBarbancho-Fernandez, Miguel Angel 
dc.contributor.authorDawid-Milner, Marc Stefan 
dc.date.accessioned2018-07-16T11:30:21Z
dc.date.available2018-07-16T11:30:21Z
dc.date.created2018-07
dc.date.issued2018-07-16
dc.identifier.urihttps://hdl.handle.net/10630/16277
dc.description.abstractThis study has been performed in spontaneously breathing anesthetised rats. We have analysed the possible interactions between the midbrain dorsolateral periaqueductal grey matter (dlPAG) and the pontine A5 region. Electrical stimulations of the dlPAG (1 ms pulses, 20-30 μA given at 100 Hz for 5s) were elicited and the evoked cardiorespiratory changes were analysed before and after ipsilateral blockade of the neurotransmission within the A5 region by means of microinjections of muscimol (50 nl, 0.25 nmol, 5s). Electrical stimulations evoked the classical “defence response” characterized by tachipnoea, hypertension and tachycardia. Tachipnoea consisted of an inspiratory facilitatory response [increase in respiratory rate (p<0.001) due to a decrease in expiratory time (p<0.01)] and was accompanied by a pressor (p<0.001) and tachycardic (p<0.001) response. Muscimol microinjected within the A5 region reduced pressor (p<0.05), tachycardic (p<0.001) and tachypnoeic (p<0.001) responses evoked to dlPAG electrical stimulations. Finally, in order to assess functional interactions between A5 and dlPAG, extracellular recordings of 40 putative A5 cells during dlPAG electrical stimulation were recorded. 16 cells were affected by dlPAG stimulation (40%). 3 cells showed orthodromic activation (14.2 ± 1.7 ms). 5 cells were excited (10.1 ± 1.6 ms). 7 cells decreased spontaneous activity to dlPAG stimulation. 24 cells were not modified by dlPAG stimulation (2 presented a respiratory pattern and 1 presented a cardiovascular pattern). These results contribute with new data on the role of the A5 region neurones in the modulation of the cardiorespiratory response evoked on dlPAG stimulation.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Techen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeurociencias - Congresosen_US
dc.subject.otherA5 regionen_US
dc.subject.otherRespiratory controlen_US
dc.subject.otherCardiovascular controlen_US
dc.subject.otherRaten_US
dc.subject.otherDorsolateral periaqueductal grey matteren_US
dc.titleDoes the midbrain dorsolateral periaqueductal grey have direct connections with the pontine A5 region? A neuropharmacologic and electrophysiological studyen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Medicinaen_US
dc.relation.eventtitle11th FENS FORUM OF NEUROSCIENCEen_US
dc.relation.eventplaceBERLIN, ALEMANIAen_US
dc.relation.eventdate7 DE JULIO DE 2018en_US


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