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dc.contributor.authorEl-Azaz Ciudad, Jorge
dc.contributor.authorCanovas-Ramos, Francisco Miguel 
dc.contributor.authorÁvila, Concepción
dc.contributor.authorDe la Torre Fazio, Fernando
dc.date.accessioned2018-07-25T07:18:05Z
dc.date.available2018-07-25T07:18:05Z
dc.date.created2018
dc.date.issued2018-07-25
dc.identifier.urihttps://hdl.handle.net/10630/16352
dc.description.abstractPhenylalanine (Phe) biosynthesis in plants is a key process, as Phe serves as precursor of proteins and phenylpropanoids. The prephenate pathway connects chorismate, final product of the shikimate pathway, with the biosynthesis of Phe and Tyr. Two alternative routes of Phe biosynthesis have been reported: one depending of arogenate, and the other of phenylpyruvate. Whereas the arogenate pathway is considered the main route, the role of the phenylpyruvate pathway remains unclear. Here, we report that the deficiency in ADT2, a bifunctional arogenate dehydratase (ADT)/ prephenate dehydratase (PDT) enzyme, causes embryo arrest and seed abortion. This result makes a clear distinction between the essential role of ADT2 and the five remaining ADTs from Arabidopsis, which display mostly overlapping functions. We have found that PHA2, a monofunctional PDT from yeast, restores the adt2 phenotype when is targeted within the plastids, but not when is expressed in the cytosol. Similar results can be obtained by expressing ADT3, a monofunctional ADT. These results suggest that Phe can be synthesized from phenylpyruvate or arogenate when the bifunctional ADT2 is replaced by other ADT or PDT enzymes during seed formation, highlighting the importance of Phe for embryo development, and providing further insights into the plasticity of Phe biosynthesis.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFenilalanina - Síntesisen_US
dc.subject.otherPhenylalanine biosynthesisen_US
dc.subject.otherArogenate dehydrataseen_US
dc.titleThe arogenate dehydratase ADT2 is essential for seed development in Arabidopsisen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitlePlant Biology 2018en_US
dc.relation.eventplaceMontreal, Québec (Canadá)en_US
dc.relation.eventdate14 al 18 de Julio 2018en_US


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