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dc.contributor.authorMarrero, Ana Dácil
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorCastillo, Laura
dc.contributor.authorGallardo, Elena
dc.contributor.authorEspartero, José L.
dc.contributor.authorCarrillo Fernández, Paloma
dc.contributor.authorRodriguez-Quesada, Ana Maria 
dc.contributor.authorMedina, Miguel Ángel 
dc.date.accessioned2018-09-19T12:03:05Z
dc.date.available2018-09-19T12:03:05Z
dc.date.created2018
dc.date.issued2018-09-19
dc.identifier.urihttps://hdl.handle.net/10630/16495
dc.description.abstractAngiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing interest showed by many groups of research and pharmaceutical companies to find compounds with potential to disrupt at least one of the steps within the angiogenic process. Hydroxytyrosol (3,4-dihydroxyphenyl ethanol) has been identified as the most important health-related phenolic compound of virgin olive oil because of its pleiotropic effects on multiple targets. In 2012, our group identified hydroxytyrosol as an anti-angiogenic compound able to inhibit several key steps in the angiogenic process. In the present study, the potential effects of six hydroxytyrosol derivatives are tested and compared with those exhibited by hydroxytyrosol by making use of several in vitro and in vivo assays. Results indicate that these are candidate new anti-angiogenic compounds with potential utility in anti-tumor and anti-angiogenic therapies.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communication has the support of a travel grant.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeovascularizaciónen_US
dc.subjectBiología molecularen_US
dc.subject.otherHydroxytyrosolen_US
dc.titleEvaluation of the anti-angiogenic potential of hydroxytyrosol derivativesen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitle41 Congreso de la Sociedad Española de Bioquímica y Biología Molecular SEBBM18en_US
dc.relation.eventplaceSantanderen_US
dc.relation.eventdateDel 10 al 13 de septiembre de 2018en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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