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dc.contributor.authorCheng-Sánchez, Iván
dc.contributor.authorCarrillo Fernández, Paloma
dc.contributor.authorMartínez-Póveda, Beatriz Amparo 
dc.contributor.authorRodríguez-Quesada, Ana María 
dc.contributor.authorMedina-Torres, Miguel Ángel 
dc.contributor.authorSarabia-García, Francisco Ramón 
dc.date.accessioned2018-10-15T10:48:39Z
dc.date.available2018-10-15T10:48:39Z
dc.date.created2018
dc.date.issued2018-10-15
dc.identifier.urihttps://hdl.handle.net/10630/16609
dc.description.abstractSolomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, solomonamide A exhibits anti-inflammatory activity, showing potent reduction (60%) of inflammation at a very low concentration of 100 µg/kg in animal models. However, the scarcity of these compounds from their natural sources has been a drawback for further pharmacological assays. In fact, the anti-inflammatory activity of solomonamide B was not evaluated due to the limited amounts. This difficulty to access large amounts of these compounds makes quite difficult to gain insight into their biological profiles and mechanism of action and justifies the chemical synthesis of this new class of cyclic peptides. As a consequence, the solomonamides have been the subject of several synthetic efforts [2] notably by the Reddy group who has recently reported the first total synthesis of solomonamide B based on a intramolecular Heck reaction, which led to a revision of the initially proposed structure for 2 [3].en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProductos naturalesen_US
dc.subject.otherTotal synthesisen_US
dc.subject.otherNatural productsen_US
dc.subject.otherAntitumoralen_US
dc.subject.otherSolomonamidesen_US
dc.subject.otherRing-closing metathesisen_US
dc.titleSynthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamidesen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleXXII International Conference on Organic Synthesisen_US
dc.relation.eventplaceFlorenciaen_US
dc.relation.eventdateSeptiembre, 2018en_US


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