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dc.contributor.authorGarcía-Caballero, Melissa
dc.contributor.authorRodriguez-Quesada, Ana Maria 
dc.contributor.authorMedina Torres, Miguel Ángel
dc.contributor.authorMari-Beffa, Manuel 
dc.date.accessioned2018-10-19T07:38:40Z
dc.date.available2018-10-19T07:38:40Z
dc.date.created2018
dc.date.issued2018-10-19
dc.identifier.urihttps://hdl.handle.net/10630/16662
dc.description.abstractZebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph) angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.en_US
dc.description.sponsorshipOur experimental work was supported by grants BIO2014-56092-R (Spanish Ministry of Economy and Competitiveness and FEDER), and PIE P12-CTS-1507,CVI-6585 and funds from group BIO-267 (Andalucian Government and FEDER). CIBER de Enfermedades Raras and CIBER de Bioingenierı´a, Biomateriales y Nanomedicina are initiatives from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeovascularizaciónen_US
dc.subject.otherAngiogenesisen_US
dc.subject.otherZebrafishen_US
dc.subject.otherLymphangiogenesisen_US
dc.titleFishing anti(lymph)angiogenic drugs with zebrafishen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.centroFacultad de Cienciasen_US
dc.identifier.doi10.1016/j.drudis.2017.10.018
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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