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Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
dc.contributor.author | Cheng-Sánchez, Iván | |
dc.contributor.author | Sánchez-Ruiz, Antonio | |
dc.contributor.author | Martínez-Poveda, Beatriz | |
dc.contributor.author | Medina Torres, Miguel Ángel | |
dc.contributor.author | Carrillo Fernández, Paloma | |
dc.contributor.author | Rodriguez-Quesada, Ana Maria | |
dc.contributor.author | López-Romero, Juan Manuel | |
dc.contributor.author | Sarabia-Garcia, Francisco Ramon | |
dc.date.accessioned | 2018-10-19T10:23:04Z | |
dc.date.available | 2018-10-19T10:23:04Z | |
dc.date.created | 2018 | |
dc.date.issued | 2018-10-19 | |
dc.identifier.uri | https://hdl.handle.net/10630/16666 | |
dc.description.abstract | New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized systems, and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core. The described synthetic strategies toward the solomonamides are well suited for the subsequent access to the natural products and represent flexible and diversityoriented routes that allow for the generation of a variety of analogues via oxidative transformations. In addition, preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines. | en_US |
dc.description.sponsorship | This work was financially supported by the Ministerio de Economía y Competitividad (MINECO) (ref BIO2014-56092-R, CTQ2014-60223-R and CTQ2016-76311-R) and Junta de Andalucía and “Fondo Europeo de Desarrollo Regional-FEDER” (P12 CTS-1507). I.C.-S. thanks Ministerio de Educación, Cultura y Deporte for a predoctoral fellowship (FPU programme). | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cáncer | en_US |
dc.subject.other | Metathesis | en_US |
dc.subject.other | Solomonamide | en_US |
dc.subject.other | Bioactive precursors | en_US |
dc.subject.other | Antitumor | en_US |
dc.title | Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.centro | Facultad de Ciencias | en_US |
dc.identifier.doi | 10.1021/acs.joc.7b02988 | |
dc.rights.cc | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |