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dc.contributor.authorCheng-Sánchez, Iván
dc.contributor.authorSánchez-Ruiz, Antonio
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorMedina Torres, Miguel Ángel
dc.contributor.authorCarrillo Fernández, Paloma
dc.contributor.authorRodriguez-Quesada, Ana Maria 
dc.contributor.authorLópez-Romero, Juan Manuel 
dc.contributor.authorSarabia-Garcia, Francisco Ramon 
dc.date.accessioned2018-10-19T10:23:04Z
dc.date.available2018-10-19T10:23:04Z
dc.date.created2018
dc.date.issued2018-10-19
dc.identifier.urihttps://hdl.handle.net/10630/16666
dc.description.abstractNew synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized systems, and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core. The described synthetic strategies toward the solomonamides are well suited for the subsequent access to the natural products and represent flexible and diversityoriented routes that allow for the generation of a variety of analogues via oxidative transformations. In addition, preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines.en_US
dc.description.sponsorshipThis work was financially supported by the Ministerio de Economía y Competitividad (MINECO) (ref BIO2014-56092-R, CTQ2014-60223-R and CTQ2016-76311-R) and Junta de Andalucía and “Fondo Europeo de Desarrollo Regional-FEDER” (P12 CTS-1507). I.C.-S. thanks Ministerio de Educación, Cultura y Deporte for a predoctoral fellowship (FPU programme).en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCánceren_US
dc.subject.otherMetathesisen_US
dc.subject.otherSolomonamideen_US
dc.subject.otherBioactive precursorsen_US
dc.subject.otherAntitumoren_US
dc.titleExploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursorsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.centroFacultad de Cienciasen_US
dc.identifier.doi10.1021/acs.joc.7b02988
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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