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dc.contributor.authorRodríguez-Pérez, Luis Manuel
dc.contributor.authorJiménez, Antonio J
dc.contributor.authorPáez-González, Patricia
dc.date.accessioned2018-10-30T11:44:59Z
dc.date.available2018-10-30T11:44:59Z
dc.date.created2018-10-21
dc.date.issued2018-10-30
dc.identifier.urihttps://hdl.handle.net/10630/16767
dc.description.abstractIntroduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) severe damage of the underlying periventricular nervous tissue, including white matter, and c). Therapeutic approaches have been directed to overcome a) and b), however recovery of damaged neuroepithelium/ependyma is, in our present, an important therapeutic gap. Methods: Human and mouse induced pluripotent stem cells (iPSC) have been artificially differented into ependymal progenitors. Intracerebroventricular (ICV) injections of iPCS are performed ex vivo and in vivo in the damaged ventricular wall. Their integration and differentiation has been studied by immunohistochemistry and histopathological analysis. Results: Mice and human ependymal progenitors are able to integrate and differentiate into ependyma in damaged ventricular wall. Stage of ependymal differentiation by the time of the injection defined different degrees of integration. Conclusions: IPSC appear to be a good ependymal progenitor source with no ethical controversy associated.en_US
dc.description.sponsorshipRyC 2014-16980 Universidad de Málaga. Campus de Excelencia Internacional Andalucía Techen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHidrocefaliaen_US
dc.subject.otheriPSCen_US
dc.subject.otherHydrocephalusen_US
dc.subject.otherEpendymaen_US
dc.titleIPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalusen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleHydrocephalus 2018en_US
dc.relation.eventplaceBolonia, Italiaen_US
dc.relation.eventdate19-22/10/2018en_US


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